PMID- 30536073
OWN - NLM
STAT- MEDLINE
DCOM- 20190319
LR  - 20190319
IS  - 2523-899X (Electronic)
IS  - 2523-899X (Linking)
VI  - 38
IP  - 6
DP  - 2018 Dec
TI  - Upregulation of UBAP2L in Bone Marrow Mesenchymal Stem Cells Promotes Functional 
      Recovery in Rats with Spinal Cord Injury.
PG  - 1081-1089
LID - 10.1007/s11596-018-1987-x [doi]
AB  - Post-translational modifications of cellular proteins with ubiquitin or 
      ubiquitin-like proteins regulate many cellular processes, such as cell 
      proliferation, differentiation, apoptosis, signal transduction, intercellular 
      immune recognition, inflammatory response, stress response, and DNA repair. 
      Nice4/UBAP2L is an important member in the family of ubiquitin-like proteins, and 
      its biological function remains unknown. This study aimed to investigate the 
      effect of UBAP2L on spinal cord injury (SCI). At first, rat bone marrow 
      mesenchymal stem cells (BMSCs) were infected with adeno-associated virus to 
      induce over-expression of Nice4. Subsequently, the infected BMSCs were 
      transplanted into rats suffering from semi-sectioned SCI. The results showed that 
      the over-expression of Nice4 significantly promoted the proliferation and 
      differentiation of BMSCs. In addition, the transplantation of infected BMSCs into 
      the injured area of SCI rats improved the function repair of SCI. Importantly, 
      the immunohistochemical and hematoxylin-eosin staining and RT-PCR results showed 
      that the number of neuronal cells, oligodendrocytes, and astrocytes was 
      significantly increased in the injured area, along with significantly upregulated 
      expression of cyclin D1 and p38 mitogen-activated protein kinase (MAPK). 
      Meanwhile, the expression of caspase 3 protein was significantly down-regulated. 
      In conclusion, the over-expression of Nice4 gene can promote the functional 
      recovery in SCI rats by promoting cell proliferation and inhibiting apoptosis. 
      The results of this study indicate an alternative option for the clinical 
      treatment of SCI.
FAU - Lin, Guan-Lin
AU  - Lin GL
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Wang, Huan
AU  - Wang H
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Dai, Jun
AU  - Dai J
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Li, Xiao
AU  - Li X
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Guan, Ming
AU  - Guan M
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Ding, Qing
AU  - Ding Q
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Wang, Huai-Xi
AU  - Wang HX
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Fang, Huang
AU  - Fang H
AD  - Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China. fanghuangtjh@126.com.
LA  - eng
PT  - Journal Article
DEP - 20181207
PL  - China
TA  - Curr Med Sci
JT  - Current medical science
JID - 101729993
RN  - 0 (Carrier Proteins)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Carrier Proteins/*genetics
MH  - Cell Differentiation/*genetics
MH  - Cell Proliferation/genetics
MH  - Cells, Cultured
MH  - Down-Regulation/genetics
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/methods
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Neurons/metabolism/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function/*genetics
MH  - Signal Transduction/genetics
MH  - Spinal Cord Injuries/*genetics/metabolism/*physiopathology
MH  - Up-Regulation/*genetics
OTO - NOTNLM
OT  - apoptosis
OT  - bone marrow mesenchymal stem cells
OT  - proliferation
OT  - spinal cord injury
OT  - ubiquitin-associated protein 2-like
EDAT- 2018/12/12 06:00
MHDA- 2019/03/20 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/03/07 00:00 [received]
PHST- 2018/06/12 00:00 [revised]
PHST- 2018/12/12 06:00 [entrez]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/03/20 06:00 [medline]
AID - 10.1007/s11596-018-1987-x [pii]
AID - 10.1007/s11596-018-1987-x [doi]
PST - ppublish
SO  - Curr Med Sci. 2018 Dec;38(6):1081-1089. doi: 10.1007/s11596-018-1987-x. Epub 2018 
      Dec 7.