PMID- 30536092
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20200225
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 1905
DP  - 2019
TI  - Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver 
      Regeneration.
PG  - 83-90
LID - 10.1007/978-1-4939-8961-4_8 [doi]
AB  - Following massive hepatocyte ablation in zebrafish, biliary epithelial cells can 
      extensively give rise to hepatocytes through liver progenitor cells (LPCs). The 
      zebrafish liver injury model is an important system to elucidate the molecular 
      mechanisms underlying LPC-driven liver regeneration. Here, we describe a chemical 
      screening method using the zebrafish model for identifying small molecules that 
      can modulate LPC-driven liver regeneration.
FAU - Ko, Sungjin
AU  - Ko S
AD  - Department of Developmental Biology, McGowan Institute for Regenerative Medicine, 
      Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Shin, Donghun
AU  - Shin D
AD  - Department of Developmental Biology, McGowan Institute for Regenerative Medicine, 
      Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA. 
      donghuns@pitt.edu.
LA  - eng
GR  - R01 DK101426/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Small Molecule Libraries)
SB  - IM
MH  - Ablation Techniques
MH  - Animals
MH  - Cell Dedifferentiation
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Disease Models, Animal
MH  - Hepatocytes/*cytology/metabolism
MH  - Liver Regeneration/*drug effects
MH  - Small Molecule Libraries/*pharmacology
MH  - Stem Cells/*cytology/metabolism
MH  - Zebrafish
PMC - PMC6423532
MID - NIHMS1007973
OTO - NOTNLM
OT  - Biliary epithelial cells
OT  - Chemical screen
OT  - Hepatocyte ablation
OT  - Liver progenitor cells
OT  - Nitroreductase
EDAT- 2018/12/12 06:00
MHDA- 2019/06/14 06:00
PMCR- 2020/01/01
CRDT- 2018/12/12 06:00
PHST- 2018/12/12 06:00 [entrez]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.1007/978-1-4939-8961-4_8 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2019;1905:83-90. doi: 10.1007/978-1-4939-8961-4_8.