PMID- 30537707
OWN - NLM
STAT- MEDLINE
DCOM- 20200617
LR  - 20200617
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Print)
IS  - 1011-7571 (Linking)
VI  - 28
IP  - 3
DP  - 2019
TI  - Blue Rubber Bleb Nevus Syndrome: A Possible Cause for Growth Retardation and 
      Pubertal Delay.
PG  - 294-296
LID - 10.1159/000496105 [doi]
AB  - OBJECTIVE: The aim of this paper was to describe a rare case of blue rubber bleb 
      nevus (BRBNS) with growth retardation and pubertal delay. CLINICAL PRESENTATION 
      AND INTERVENTION: A 16-year-old boy with severe iron deficiency anemia was 
      diagnosed with BRBNS, showing growth retardation and pubertal delay 
      simultaneously. The patient was treated conservatively with intravenous iron 
      therapy, and his puberty advanced gradually. CONCLUSION: Given that growth 
      retardation and pubertal delay are rare in BRBNS patients, this case reminds us 
      to include BRBNS in the differential diagnosis of growth retardation.
CI  - (c) 2019 The Author(s) Published by S. Karger AG, Basel.
FAU - Pan, Yi
AU  - Pan Y
AD  - Department of Hematology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - Department of Hematology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing, China, 
      pumczhanglu@126.com.
FAU - Duan, Minghui
AU  - Duan M
AD  - Department of Hematology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Yang, Hong
AU  - Yang H
AD  - Department of Gastroenterology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Zhao, Duoduo
AU  - Zhao D
AD  - Department of Hematology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Li, Weifeng
AU  - Li W
AD  - Department of Hematology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Case Reports
DEP - 20181210
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University, 
      Health Science Centre
JID - 8901334
RN  - E1UOL152H7 (Iron)
RN  - Blue rubber bleb nevus syndrome
SB  - IM
MH  - Adolescent
MH  - Anemia, Iron-Deficiency/*complications/drug therapy
MH  - Gastrointestinal Neoplasms/*complications
MH  - Growth Disorders/*complications
MH  - Humans
MH  - Iron/therapeutic use
MH  - Male
MH  - Nevus, Blue/*complications
MH  - Puberty, Delayed/*complications
MH  - Skin Neoplasms/*complications
PMC - PMC6597915
OTO - NOTNLM
OT  - Blue rubber bleb nevus syndrome
OT  - Growth retardation
OT  - Iron deficiency anemia
OT  - Pubertal delay
COIS- The authors have no conflicts of interest to declare.
EDAT- 2018/12/12 06:00
MHDA- 2020/06/18 06:00
PMCR- 2018/12/10
CRDT- 2018/12/12 06:00
PHST- 2018/06/12 00:00 [received]
PHST- 2018/12/10 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2020/06/18 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
PHST- 2018/12/10 00:00 [pmc-release]
AID - 000496105 [pii]
AID - mpp-0028-0294 [pii]
AID - 10.1159/000496105 [doi]
PST - ppublish
SO  - Med Princ Pract. 2019;28(3):294-296. doi: 10.1159/000496105. Epub 2018 Dec 10.