PMID- 30538284 OWN - NLM STAT- MEDLINE DCOM- 20200713 LR - 20220416 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 43 IP - 12 DP - 2019 Dec TI - Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles. PG - 2518-2527 LID - 10.1038/s41366-018-0282-z [doi] AB - BACKGROUND/OBJECTIVE: Biliopancreatic diversion with duodenal switch (BPD-DS) is the most effective bariatric intervention to treat morbid obesity and related disorders. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a new bariatric procedure devised with the purpose of simplifying the complexity of the BPD-DS technique while maintaining its efficacy. However, whether BPD-DS and SADI-S result in similar fasting and post-prandial hormone profiles has not yet been studied. Therefore, the purpose of this study was to assess and compare the hormone response to a standardized mixed meal in subjects operated with BPD-DS or SADI-S. SUBJECTS/METHODS: Subjects submitted to BPD-DS (n = 9) or SADI-S (n = 9) 1.5 years earlier on average, with no past nor current diabetes diagnosis underwent a liquid mixed-meal tolerance test (MMTT) to assess the baseline and post-prandial profile of glucose, enteropancreatic hormones and total bile acids. RESULTS: Fasting glucose, enteropancreatic hormones and total bile acids levels after BPD-DS and SADI-S were similar. After the MMTT, the response of subjects who underwent SADI-S was characterized by higher glucose (t = 30 min: p < 0.05; iAUC: 156.1 +/- 46.2 vs. 103.4 +/- 35.8 mmol/L x min, p = 0.02), GLP-1 (t = 30 min: p < 0.05; iAUC: 5388 +/- 3010 vs. 2959.0 +/- 2146 pmol/L x min, p = 0.02), glucagon (t = 30 min: p < 0.05; iAUC: 678.7 +/- 295.2 vs. 376.9 +/- 215.7 pmol/L x min, p = 0.02), insulin (t = 30 and 45 min: p < 0.05); and C-peptide levels (t = 30 and 45 min: p < 0.05), when compared to BPD-DS. CONCLUSIONS: The post-prandial hormone secretion profile after SADI-S is characterized by increased GLP-1, glucagon and insulin secretion, when compared to BPD-DS, which suggests the existence of different endocrine driven mechanisms leading to weight loss and metabolic improvement after the two procedures. FAU - Pereira, Sofia S AU - Pereira SS AUID- ORCID: 0000-0001-6947-4560 AD - Unit for Multidisciplinary Research in Biomedicine (UMIB), Endocrine, Cardiovascular and Metabolic Research, University of Porto, Porto, Portugal. AD - Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal. FAU - Guimaraes, Marta AU - Guimaraes M AD - Unit for Multidisciplinary Research in Biomedicine (UMIB), Endocrine, Cardiovascular and Metabolic Research, University of Porto, Porto, Portugal. AD - Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal. AD - Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal. FAU - Almeida, Rui AU - Almeida R AD - Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal. FAU - Pereira, Ana M AU - Pereira AM AD - Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal. FAU - Lobato, Carolina B AU - Lobato CB AUID- ORCID: 0000-0003-3708-6859 AD - Unit for Multidisciplinary Research in Biomedicine (UMIB), Endocrine, Cardiovascular and Metabolic Research, University of Porto, Porto, Portugal. AD - Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal. FAU - Hartmann, Bolette AU - Hartmann B AD - Faculty of Health Sciences, Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. FAU - Hilsted, Linda AU - Hilsted L AD - Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Holst, Jens J AU - Holst JJ AD - Faculty of Health Sciences, Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. FAU - Nora, Mario AU - Nora M AD - Unit for Multidisciplinary Research in Biomedicine (UMIB), Endocrine, Cardiovascular and Metabolic Research, University of Porto, Porto, Portugal. AD - Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal. FAU - Monteiro, Mariana P AU - Monteiro MP AUID- ORCID: 0000-0002-0662-1831 AD - Unit for Multidisciplinary Research in Biomedicine (UMIB), Endocrine, Cardiovascular and Metabolic Research, University of Porto, Porto, Portugal. mpmonteiro@icbas.up.pt. AD - Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal. mpmonteiro@icbas.up.pt. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181211 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 RN - 0 (Gastrointestinal Hormones) SB - IM MH - Adult MH - Anastomosis, Surgical MH - Bariatric Surgery/*methods MH - Biliopancreatic Diversion/*methods MH - Cohort Studies MH - Duodenum/surgery MH - Female MH - Gastrectomy MH - Gastrointestinal Hormones/*blood MH - Humans MH - Ileum/surgery MH - Male MH - Middle Aged MH - Obesity, Morbid/surgery MH - Postprandial Period/*physiology MH - Treatment Outcome MH - Young Adult EDAT- 2018/12/13 06:00 MHDA- 2020/07/14 06:00 CRDT- 2018/12/13 06:00 PHST- 2018/08/27 00:00 [received] PHST- 2018/11/19 00:00 [accepted] PHST- 2018/11/05 00:00 [revised] PHST- 2018/12/13 06:00 [pubmed] PHST- 2020/07/14 06:00 [medline] PHST- 2018/12/13 06:00 [entrez] AID - 10.1038/s41366-018-0282-z [pii] AID - 10.1038/s41366-018-0282-z [doi] PST - ppublish SO - Int J Obes (Lond). 2019 Dec;43(12):2518-2527. doi: 10.1038/s41366-018-0282-z. Epub 2018 Dec 11.