PMID- 30539067
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 6
IP  - 12
DP  - 2018 Dec
TI  - Endoscopic suturing for management of peptic ulcer-related upper gastrointestinal 
      bleeding: a preliminary experience.
PG  - E1439-E1444
LID - 10.1055/a-0749-0011 [doi]
AB  - Background and study aims  Acute non-variceal upper gastrointestinal bleeding 
      (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging 
      emergency managed by gastroenterologists. The proper role of endoscopic suturing 
      on the management of PUD-related UGIB is unknown. Patients and methods  This is 
      an international case series of patients who underwent endoscopic suturing for 
      bleeding PUD. Primary outcome was rate of immediate hemostasis and rate of early 
      rebleeding (within 72 hours). Secondary outcomes included technical success, 
      delayed rebleeding (> 72 hours), and rate of adverse events (AEs). Results  Ten 
      patients (mean age 66.7 years, 30 % female) were included in this study. Nine 
      (90 %) had prior failed endoscopy hemostasis with an average of 1.4 +/- 0.7 (range 
      1 - 3) prior endoscopic sessions. Forrest classification was Ib in 5 (50 %), IIa 
      in 3 (30 %), IIb in 1(10 %), and IIc in 1 (10 %). Mean suturing time was 
      13.4 +/- 5.6 (range 3.5 to 20) minutes. Technical success was 100 %. Rate of 
      immediate hemostasis was 100 % and rate of early rebleeding was 0 %. Mean number 
      of sutures was 1.5 (range, 1 - 4). No AEs were observed. Delayed recurrent 
      bleeding was not observed in any cases after a median of 11 months (range 
      2 - 56), after endoscopic suturing. Conclusions  Oversewing of a bleeding or 
      high-risk ulcer using endoscopic suturing appears to be a safe and effective 
      method for achieving endoscopic hemostasis. It may be considered as rescue 
      endoscopic therapy when primary endoscopic hemostasis fails to control the 
      bleeding or when hemorrhage recurs after successful control of bleeding.
FAU - Agarwal, Amol
AU  - Agarwal A
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Benias, Petros
AU  - Benias P
AD  - Division of Gastroenterology, North Shore-Long Island Jewish Medical Center, 
      Queens, NY.
FAU - Brewer Gutierrez, Olaya I
AU  - Brewer Gutierrez OI
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Wong, Vivien
AU  - Wong V
AD  - Department of Surgery, Chinese University of Hong Kong, Hong Kong.
FAU - Hanada, Yuri
AU  - Hanada Y
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Yang, Juliana
AU  - Yang J
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Villgran, Vipin
AU  - Villgran V
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Kumbhari, Vivek
AU  - Kumbhari V
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Kalloo, Anthony
AU  - Kalloo A
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Khashab, Mouen A
AU  - Khashab MA
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
FAU - Chiu, Philip
AU  - Chiu P
AD  - Department of Surgery, Chinese University of Hong Kong, Hong Kong.
FAU - Ngamruengphong, Saowanee
AU  - Ngamruengphong S
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.
LA  - eng
PT  - Journal Article
DEP - 20181210
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC6288763
COIS- Competing interests Dr. Kumbhari is a consultant for Boston Scientific, Apollo 
      Endosurgery, Medtronic, and ReShape Medical. Dr. Kalloo is a founding member, 
      equity holder, and consultant for Apollo Endosurgery. Dr. Khashab is a consultant 
      for Boston Scientific.
EDAT- 2018/12/13 06:00
MHDA- 2018/12/13 06:01
PMCR- 2018/12/01
CRDT- 2018/12/13 06:00
PHST- 2018/06/30 00:00 [received]
PHST- 2018/08/30 00:00 [accepted]
PHST- 2018/12/13 06:00 [entrez]
PHST- 2018/12/13 06:00 [pubmed]
PHST- 2018/12/13 06:01 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.1055/a-0749-0011 [doi]
PST - ppublish
SO  - Endosc Int Open. 2018 Dec;6(12):E1439-E1444. doi: 10.1055/a-0749-0011. Epub 2018 
      Dec 10.