PMID- 30540488
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20221207
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 38
IP  - 2
DP  - 2019 Feb
TI  - PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis 
      in Chinese Population.
PG  - 121-128
LID - 10.1089/dna.2018.4417 [doi]
AB  - Acute anterior uveitis (AAU) is an ordinary type of uveitis, which is an 
      autoimmune disease produced by T cells. Programmed apoptosis protein 1 (PD-1) is 
      a vital negative regulatory protein of immune tolerance. We detect the single 
      nucleotide polymorphisms (SNPs) rs41386349, rs10204525, and rs2227982 of PD-1 to 
      investigate the correlation between PD-1 polymorphisms and AAU. A total of 166 
      AAU patients and 263 controls were recruited in this case-control study. Compared 
      with controls, the frequencies of the GG genotypes were higher in rs10204525 in 
      AAU patients (p = 0.012). There were obvious increases in frequencies of the TT 
      genotypes in rs2227982 and the GG genotypes in rs10204525 in human leukocyte 
      antigen (HLA)-B27-negative AAU patients compared with controls (p = 0.03; 
      p = 0.015, respectively). There were also increases in frequencies of TT 
      genotypes in rs2227982 and the GG genotypes in rs10204525 in the patients without 
      ankylosing spondylitis (AS) when compared with controls (p = 0.021; p = 0.003, 
      respectively). Furthermore, the frequencies of TT genotypes in rs2227982 were 
      higher in female patients diagnosed with AAU than with control group (p = 0.033). 
      Our results showed that SNPs rs2227982 and rs10204525 were interrelated to AAU; 
      the influence on AAU could be related with gender, HLA-B27, and AS status.
FAU - Li, Yuyu
AU  - Li Y
AD  - 1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and 
      Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Hong, Meng
AU  - Hong M
AD  - 2 State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 
      Zhejiang, China.
FAU - Huang, Xianhui
AU  - Huang X
AD  - 3 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of 
      Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and 
      Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Zhong, Liping
AU  - Zhong L
AD  - 3 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of 
      Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and 
      Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Gu, Yunfeng
AU  - Gu Y
AD  - 1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and 
      Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Wang, Daxuan
AU  - Wang D
AD  - 1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and 
      Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Wang, Yuqin
AU  - Wang Y
AD  - 1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and 
      Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Lan, Yuan
AU  - Lan Y
AD  - 1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and 
      Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Lou, Yongliang
AU  - Lou Y
AD  - 3 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of 
      Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and 
      Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Zheng, Meiqin
AU  - Zheng M
AD  - 1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and 
      Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20181212
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-B27 Antigen/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Programmed Cell Death 1 Receptor/*genetics
MH  - Spondylitis, Ankylosing/genetics
MH  - Uveitis, Anterior/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - acute anterior uveitis
OT  - ankylosing spondylitis
OT  - human leukocyte antigen-B27
OT  - programmed apoptosis protein 1
OT  - single nucleotide polymorphisms
EDAT- 2018/12/13 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/12/13 06:00
PHST- 2018/12/13 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/12/13 06:00 [entrez]
AID - 10.1089/dna.2018.4417 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2019 Feb;38(2):121-128. doi: 10.1089/dna.2018.4417. Epub 2018 Dec 
      12.