PMID- 30540571
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200109
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 43
IP  - 3
DP  - 2019 Mar
TI  - Gray-zone Lymphoma Between cHL and Large B-Cell Lymphoma: A Histopathologic 
      Series From the LYSA.
PG  - 341-351
LID - 10.1097/PAS.0000000000001198 [doi]
AB  - Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin 
      lymphoma (cHL) and large B-cell lymphoma (LBCL) was introduced as a provisional 
      entity into the World Health Organization classification in 2008. However, as 
      diagnostic criteria are imprecise, reliable identification of GZL cases remains 
      challenging. Here, we describe the histopathologic features of 139 GZL cases from 
      a retrospective Lymphoma Study Association (LYSA) study with the goal to improve 
      classification accuracy. Inclusion criteria were based on literature review and 
      an expert consensus opinion of the LYSA hematopathologist panel. We observed 86 
      cases with a morphology more closely related to cHL, but with an LBCL 
      immunophenotype based on strong and homogenous B-cell marker expression (CD20 
      and/or CD79a, OCT2, BOB1, PAX5) on all tumor cells (cHL-like GZL). Fifty-three 
      cases were morphologically more closely related to LBCL but harbored a cHL 
      immunophenotype (LBCL-like GZL). Importantly, we observed a continuous 
      morphologic and immunophenotypic spectrum within these 2 GZL categories. The 
      majority of cases presented genetic immune escape features with CD274/PDCD1LG2 
      and/or CIITA structural variants by fluorescence in situ hybridization. Patients 
      without mediastinal involvement at diagnosis (17%) were older than those with 
      mediastinal tumors (median: 56 vs. 39 y). Cases associated with Epstein-Barr 
      virus (24%) presented with similar patient characteristics and outcome as 
      Epstein-Barr virus negative cases. In summary, we provide refined diagnostic 
      criteria that contribute to a more precise pathologic and clinical 
      characterization of GZL within a broad spectrum from cHL-like to LBCL-like 
      disease.
FAU - Sarkozy, Clementine
AU  - Sarkozy C
AD  - Hospital, Hematology Department, Hospices Civils Lyon, Lyon-Sud.
AD  - INSERM1052, CNRS 5286, Lyon-Sud Charles Merieux Lyon-1 Faculty, Claude Bernard 
      University.
AD  - Department for Lymphoid Cancer Research, Centre for Lymphoid Cancer, BC Cancer, 
      Vancouver, BC, Canada.
FAU - Copie-Bergman, Christiane
AU  - Copie-Bergman C
AD  - Pathology Department, Henri Mondor-Albert Chennevier Hospital, APHP, Paris 
      Est-Creteil (UPEC) University Faculty, UMR-S 955, INSERM, Creteil.
FAU - Damotte, Diane
AU  - Damotte D
AD  - Pathology Department, Groupe Hospitalier Cochin, APHP, Paris Descartes 
      University-Sorbonne Paris Cite.
FAU - Ben-Neriah, Susana
AU  - Ben-Neriah S
AD  - Department for Lymphoid Cancer Research, Centre for Lymphoid Cancer, BC Cancer, 
      Vancouver, BC, Canada.
FAU - Burroni, Barbara
AU  - Burroni B
AD  - Pathology Department, Groupe Hospitalier Cochin, APHP, Paris Descartes 
      University-Sorbonne Paris Cite.
FAU - Cornillon, Jerome
AU  - Cornillon J
AD  - Hematology Department, Lucien Neuwirth Cancer Institut, St Priest en Jarez.
FAU - Lemal, Richard
AU  - Lemal R
AD  - Hematology Department, CHU Clermont-Ferrand.
FAU - Golfier, Camille
AU  - Golfier C
AD  - Hematology Department, CHU Dijon.
FAU - Fabiani, Bettina
AU  - Fabiani B
AD  - Pathology Department, Hopital Saint Antoine, APHP.
FAU - Chassagne-Clement, Catherine
AU  - Chassagne-Clement C
AD  - Pathology Department, Centre Leon Berard, Lyon.
FAU - Parrens, Marie
AU  - Parrens M
AD  - Pathology Department, CHU de Bordeaux.
FAU - Herbaux, Charles
AU  - Herbaux C
AD  - Hematology Department, CHRU de Lille.
FAU - Xerri, Luc
AU  - Xerri L
AD  - Cancer Research Center of Marseille, Inserm U1068/CNRS U7258, Institut 
      Paoli-Calmettes, Aix Marseille Universite, Marseille.
FAU - Bossard, Celine
AU  - Bossard C
AD  - Pathology Department, CHU de Nantes.
FAU - Laurent, Camille
AU  - Laurent C
AD  - Pathology Department, Institut Universitaire du Cancer-Oncopole, CHU Toulouse, 
      INSERM, U.1037, Centre de recherche en cancerologie de Toukouse-Purpan, Toulouse.
FAU - Cheminant, Morgane
AU  - Cheminant M
AD  - Clinical Hematology, Necker-Enfants Malades University Hospital, AP-HP, Paris 
      Descartes University-Sorbonne Paris Cite, Paris.
FAU - Cartron, Guillaume
AU  - Cartron G
AD  - Hematology Department, CHU Montpellier.
FAU - Cabecadas, Jose
AU  - Cabecadas J
AD  - Departamento de Diagnostico Laboratorial, Instituto Portugues de Oncologia de 
      Lisboa-IPO, Lisbon.
FAU - Molina, Thierry
AU  - Molina T
AD  - Necker Enfants Malades Hospital, Universite Paris Descartes, APHP.
FAU - Salles, Gilles
AU  - Salles G
AD  - Hospital, Hematology Department, Hospices Civils Lyon, Lyon-Sud.
AD  - INSERM1052, CNRS 5286, Lyon-Sud Charles Merieux Lyon-1 Faculty, Claude Bernard 
      University.
FAU - Steidl, Christian
AU  - Steidl C
AD  - Department for Lymphoid Cancer Research, Centre for Lymphoid Cancer, BC Cancer, 
      Vancouver, BC, Canada.
FAU - Ghesquieres, Herve
AU  - Ghesquieres H
AD  - Hospital, Hematology Department, Hospices Civils Lyon, Lyon-Sud.
AD  - INSERM1052, CNRS 5286, Lyon-Sud Charles Merieux Lyon-1 Faculty, Claude Bernard 
      University.
FAU - Mottok, Anja
AU  - Mottok A
AD  - Department for Lymphoid Cancer Research, Centre for Lymphoid Cancer, BC Cancer, 
      Vancouver, BC, Canada.
AD  - Institute of Human Genetics, Ulm University and Ulm University Medical Center, 
      Ulm, Germany.
FAU - Traverse-Glehen, Alexandra
AU  - Traverse-Glehen A
AD  - INSERM1052, CNRS 5286, Lyon-Sud Charles Merieux Lyon-1 Faculty, Claude Bernard 
      University.
AD  - Pathology Department, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud69495 
      Pierre Benite Cedex.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lymphoma/*classification/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2018/12/13 06:00
MHDA- 2020/01/10 06:00
CRDT- 2018/12/13 06:00
PHST- 2018/12/13 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2018/12/13 06:00 [entrez]
AID - 10.1097/PAS.0000000000001198 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2019 Mar;43(3):341-351. doi: 10.1097/PAS.0000000000001198.