PMID- 30542326
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Persistent Organic Pollutants and Type 2 Diabetes: A Critical Review of Review 
      Articles.
PG  - 712
LID - 10.3389/fendo.2018.00712 [doi]
LID - 712
AB  - Low dose persistent organic pollutants (POPs) have emerged as a new risk for type 
      2 diabetes (T2D). Despite substantial evidence from human and experimental 
      studies, there are several critical issues which have not been properly addressed 
      by POPs researchers. First, as POPs exist as mixtures, findings about POPs from 
      human studies should be interpreted from the viewpoint of lipophilic chemical 
      mixtures which include both measured and unmeasured POPs. Second, as POPs can 
      directly reduce insulin secretion of beta cells, the role of POPs may be more 
      prominent in the development of beta-cell dysfunction-dominant T2D rather than 
      insulin resistance-dominant T2D. Third, there are multidimensional 
      interrelationships between POPs and adipose tissue. Even though POPs are now 
      considered as a new risk factor for T2D, independent of obesity, POPs and obesity 
      are mechanistically linked to each other. POPs are involved in key mechanisms 
      linking obesity and T2D, such as chronic inflammation of adipose tissue and 
      lipotoxicity with ectopic fat accumulation. Also, POPs can explain puzzling human 
      findings which suggest benefits of obesity because healthy adipose tissue can be 
      protective by reducing the amount of POPs reaching other organs. Fourth, 
      non-linear dose-response relationships between POPs and T2D are biologically 
      possible. Although POPs are well-known endocrine disrupting chemicals (EDCs), 
      mitochondrial dysfunction may be a more plausible mechanism due to 
      unpredictability of EDC mixtures. As adipose tissue plays a role as an internal 
      exposure source of POPs, how to manage POPs inside us may be essential to protect 
      against harms of POPs.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, South Korea.
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, MN, United States.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, South Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Daegu South Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181127
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6277786
OTO - NOTNLM
OT  - chemical mixtures
OT  - diabetes
OT  - insulin resistance
OT  - obesity
OT  - organochlorine pesticides
OT  - persistent organic pollutants
OT  - polychlorinated biphenyls
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/01/01
CRDT- 2018/12/14 06:00
PHST- 2018/07/31 00:00 [received]
PHST- 2018/11/12 00:00 [accepted]
PHST- 2018/12/14 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00712 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Nov 27;9:712. doi: 10.3389/fendo.2018.00712. 
      eCollection 2018.