PMID- 30542372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 9
DP  - 2018
TI  - Impact of Growth Hormone-Related Mutations on Mammalian Aging.
PG  - 586
LID - 10.3389/fgene.2018.00586 [doi]
LID - 586
AB  - Mutations of a single gene can lead to a major increase in longevity in organisms 
      ranging from yeast and worms to insects and mammals. Discovering these mutations 
      (sometimes referred to as "longevity genes") led to identification of 
      evolutionarily conserved molecular, cellular, and organismal mechanisms of aging. 
      Studies in mice provided evidence for the important role of growth hormone (GH) 
      signaling in mammalian aging. Mice with mutations or gene deletions leading to GH 
      deficiency or GH resistance have reduced body size and delayed maturation, but 
      are healthier and more resistant to stress, age slower, and live longer than 
      their normal (wild type) siblings. Mutations of the same genes in people can 
      provide remarkable protection from age-related disease, but have no consistent 
      impact on lifespan. Ongoing research indicates that genetic defects in GH 
      signaling are linked to extension of healthspan and lifespan via a variety of 
      interlocking mechanism, including improvements in genome and stem cell 
      maintenance, stress resistance, glucose homeostasis, and thermogenesis, along 
      with reductions in the mechanistic target of rapamycin (mTOR) C1 complex 
      signaling and in chronic low grade inflammation.
FAU - Bartke, Andrzej
AU  - Bartke A
AD  - Department of Internal Medicine, Southern Illinois University School of Medicine, 
      Springfield, IL, United States.
FAU - Quainoo, Nana
AU  - Quainoo N
AD  - Department of Biology, University of Illinois Springfield, Springfield, IL, 
      United States.
LA  - eng
GR  - P01 AG031736/AG/NIA NIH HHS/United States
GR  - R01 AG019899/AG/NIA NIH HHS/United States
GR  - R21 AG051869/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20181127
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC6278173
OTO - NOTNLM
OT  - IGF-1
OT  - aging
OT  - dwarf mice
OT  - growth hormone
OT  - healthspan
OT  - lifespan
OT  - longevity genes
OT  - somatotropic axis
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/11/27
CRDT- 2018/12/14 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/11/12 00:00 [accepted]
PHST- 2018/12/14 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/11/27 00:00 [pmc-release]
AID - 10.3389/fgene.2018.00586 [doi]
PST - epublish
SO  - Front Genet. 2018 Nov 27;9:586. doi: 10.3389/fgene.2018.00586. eCollection 2018.