PMID- 30542419
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 16
IP  - 6
DP  - 2018 Dec
TI  - Fluorescence in situ hybridization comparison of the prognostic factors in adult 
      and pediatric acute lymphoblastic leukemia: A retrospective analysis of 282 
      cases.
PG  - 4674-4684
LID - 10.3892/etm.2018.6821 [doi]
AB  - Acute lymphoblastic leukemia (ALL) affects both children and adults. However, the 
      prognosis of the two cohorts is quite different. The present aim was to review 
      and evaluate one potential cause of why survival is poorer in adult ALL than 
      pediatric ALL via fluorescence in situ hybridization (FISH). Clinical significant 
      features were analyzed in 282 ALL cases. FISH was performed to study mixed 
      lineage leukemia (MLL) translocation and the Philadelphia (Ph) chromosome in 
      newly diagnosed patients, and was used to detect trisomy 4 or 10 and the 
      translocation ETS leukemia-acute myeloid leukemia 1 (TEL-AML1) fusion gene. The 
      overall survival/event-free survival (OS/EFS) outcome of adult ALL and pediatric 
      ALL was analyzed using Kaplan-Meier analysis. Adult ALL had a higher median 
      leukocyte count and lower hemoglobin level than pediatric ALL. FISH revealed that 
      Ph positivity (Ph+) was associated with the high-risk feature of older age. In 
      pediatric ALL, trisomy 4 or 10 was present in 71/207 cases (34.3%), while the 
      TEL-AML1 fusion gene was present in 16/207 cases (7.7%). By contrast, there were 
      very few such positive cases in adult ALL. Survival analysis revealed that, in 
      adult ALL, the 3-year OS and EFS rates were higher in the Ph-negative group than 
      in the Ph+ group. Adult or pediatric ALL is an independent prognostic factor of 
      OS. The present analysis of the clinical and biological features between adult 
      and pediatric ALL indicates that adult ALL has a poorer prognosis than pediatric 
      ALL based on Ph+ status and presence of trisomy 4 or 10. Ph+ ALL is an 
      independent prognosis factor of ALL. FISH may serve an important role in the 
      comparison of prognostic factors in adult and pediatric ALL.
FAU - Cao, Pengfei
AU  - Cao P
AD  - Department of Hematology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
AD  - Cancer Research Institute, Key Laboratory of Carcinogenesis, Ministry of Health, 
      Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
FAU - Yu, Yalan
AU  - Yu Y
AD  - Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 
      430071, P.R. China.
FAU - Wang, Wei
AU  - Wang W
AD  - Cancer Research Institute, Key Laboratory of Carcinogenesis, Ministry of Health, 
      Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
FAU - Xu, He
AU  - Xu H
AD  - Cancer Research Institute, Key Laboratory of Carcinogenesis, Ministry of Health, 
      Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
FAU - He, Yuxiang
AU  - He Y
AD  - Department of Oncology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20181002
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6257547
OTO - NOTNLM
OT  - Philadelphia+ acute lymphoblastic leukemia
OT  - adult acute lymphoblastic leukemia
OT  - fluorescence in situ hybridization
OT  - pediatric acute lymphoblastic leukemia
OT  - poor survival
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/10/02
CRDT- 2018/12/14 06:00
PHST- 2017/11/30 00:00 [received]
PHST- 2018/08/31 00:00 [accepted]
PHST- 2018/12/14 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/10/02 00:00 [pmc-release]
AID - ETM-0-0-6821 [pii]
AID - 10.3892/etm.2018.6821 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Dec;16(6):4674-4684. doi: 10.3892/etm.2018.6821. Epub 2018 Oct 
      2.