PMID- 30542606
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 7
IP  - 6
DP  - 2018 Nov 1
TI  - An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B 
      in rats and rabbits.
PG  - 1225-1235
LID - 10.1039/c8tx00135a [doi]
AB  - Ginkgo biloba (a herbal product) has long been used in traditional Chinese 
      medicine to treat cerebrovascular and cardiovascular diseases. Ginkgolide B is 
      one of the important pharmacologically active components of Ginkgo biloba. 
      Dimethylaminoethyl ginkgolide B (a novel ginkgolide B derivative) has been 
      developed to overcome the poor water-solubility of natural drugs and to achieve 
      higher bioavailability. This study investigated the potential effects of 
      dimethylaminoethyl ginkgolide B on pregnant dams and embryo-fetal development in 
      Sprague-Dawley rats and New Zealand white rabbits following maternal exposure on 
      gestational day (GD) 6-15 and GD 6-18, respectively. Dimethylaminoethyl 
      ginkgolide B was administered by intravenous injection to pregnant rats (0, 10, 
      30 and 100 mg kg(-1) d(-1)) and rabbits (0, 6, 18 and 60 mg kg(-1) d(-1)). 
      Maternal toxicity signs, such as lower maternal body weight gain and food 
      consumption, were observed at 100 mg kg(-1) d(-1) in rats and 60 mg kg(-1) d(-1) 
      in rabbits. The developmental toxic effects included a decrease in fetal and 
      placental weights, increased incidences of skeletal variations and delay in fetal 
      ossification. Fetal growth and development were affected by dimethylaminoethyl 
      ginkgolide B in the high-dose group in rabbits. The no-observed-adverse-effect 
      level of dimethylaminoethyl ginkgolide B is considered to be 30 mg kg(-1) d(-1) 
      for rats and 18 mg kg(-1) d(-1) for rabbits.
FAU - Li, Ronghua
AU  - Li R
AD  - School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , 
      China . Email: hxj@njtech.edu.cn ; Email: qiaohongqun@njtech.edu.cn.
FAU - Zhang, Tingting
AU  - Zhang T
AD  - School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , 
      China . Email: hxj@njtech.edu.cn ; Email: qiaohongqun@njtech.edu.cn.
FAU - Qin, Mei
AU  - Qin M
AD  - School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , 
      China . Email: hxj@njtech.edu.cn ; Email: qiaohongqun@njtech.edu.cn.
FAU - Yue, Peng
AU  - Yue P
AD  - JiangSu Center for Safety Evaluation of Drugs , Nanjing , 211816 , China.
FAU - Cai, Ming
AU  - Cai M
AD  - JiangSu Center for Safety Evaluation of Drugs , Nanjing , 211816 , China.
FAU - He, Xuejun
AU  - He X
AD  - School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , 
      China . Email: hxj@njtech.edu.cn ; Email: qiaohongqun@njtech.edu.cn.
FAU - Qiao, Hongqun
AU  - Qiao H
AUID- ORCID: 0000-0003-3460-0883
AD  - School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , 
      China . Email: hxj@njtech.edu.cn ; Email: qiaohongqun@njtech.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180828
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC6240900
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2019/08/28
CRDT- 2018/12/14 06:00
PHST- 2018/05/12 00:00 [received]
PHST- 2018/08/27 00:00 [accepted]
PHST- 2018/12/14 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2019/08/28 00:00 [pmc-release]
AID - c8tx00135a [pii]
AID - 10.1039/c8tx00135a [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2018 Aug 28;7(6):1225-1235. doi: 10.1039/c8tx00135a. 
      eCollection 2018 Nov 1.