PMID- 30543107
OWN - NLM
STAT- MEDLINE
DCOM- 20200219
LR  - 20200219
IS  - 1535-3907 (Electronic)
IS  - 1535-3893 (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jan 4
TI  - LC-MS-Based Metabolomics and Lipidomics Study of 
      High-Density-Lipoprotein-Modulated Glucose Metabolism with an apoA-I Knockout 
      Mouse Model.
PG  - 48-56
LID - 10.1021/acs.jproteome.8b00290 [doi]
AB  - Type 2 diabetes mellitus (T2DM) has become a tremendous problem in public health 
      nowadays. High-density lipoprotein (HDL) refers to a group of heterogeneous 
      particles that circulate in blood, and a recent research finds that HDL acts a 
      pivotal part of glucose metabolism. To understand systemic metabolic changes 
      correlated with HDL in glucose metabolism, we applied LC-MS-based metabolomics 
      and lipidomics to detect metabolomic and lipidomic profiles of plasma from apoA-I 
      knockout mice fed a high-fat diet. Multivariate analysis was applied to 
      differentiate apoA-I knockout mice and controls, and potential biomarkers were 
      found. Pathway analysis demonstrated that several metabolic pathways such as 
      aminoacyl-tRNA biosynthesis, arginine and proline metabolism, and phenylalanine, 
      tyrosine, and tryptophan biosynthesis were dysregulated in apoA-I knockout mice. 
      This study may provide a new insight into the underlying pathogenesis in T2DM and 
      prove that LC-MS-based metabolomics and lipidomics are powerful approaches in 
      finding potential biomarkers and disturbed pathways.
FAU - Liu, Jia
AU  - Liu J
AUID- ORCID: 0000-0002-2845-1028
AD  - Institute of Systems Biomedicine, Department of Pathology, School of Basic 
      Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, 
      Peking-Tsinghua Center for Life Sciences , Peking University Health Science 
      Center , Beijing 100191 , China.
FAU - Zhao, Mingming
AU  - Zhao M
AD  - The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, and 
      Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education , 
      Peking University Health Science Center , Beijing 100191 , China.
FAU - Zhu, Yizhang
AU  - Zhu Y
AD  - Institute of Systems Biomedicine, Department of Pathology, School of Basic 
      Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, 
      Peking-Tsinghua Center for Life Sciences , Peking University Health Science 
      Center , Beijing 100191 , China.
FAU - Wang, Xu
AU  - Wang X
AD  - The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, and 
      Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education , 
      Peking University Health Science Center , Beijing 100191 , China.
FAU - Zheng, Lemin
AU  - Zheng L
AD  - The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, and 
      Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education , 
      Peking University Health Science Center , Beijing 100191 , China.
FAU - Yin, Yuxin
AU  - Yin Y
AD  - Institute of Systems Biomedicine, Department of Pathology, School of Basic 
      Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, 
      Peking-Tsinghua Center for Life Sciences , Peking University Health Science 
      Center , Beijing 100191 , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181213
PL  - United States
TA  - J Proteome Res
JT  - Journal of proteome research
JID - 101128775
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Lipoproteins, HDL)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Apolipoprotein A-I/deficiency/genetics
MH  - Chromatography, Liquid
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Diet, High-Fat
MH  - Glucose/*metabolism
MH  - Lipidomics/*methods
MH  - *Lipoproteins, HDL
MH  - Metabolic Networks and Pathways
MH  - Metabolomics/*methods
MH  - Mice
MH  - Mice, Knockout
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - LC-MS
OT  - apoA-I
OT  - diabetes mellitus
OT  - lipidomics
OT  - metabolomics
EDAT- 2018/12/14 06:00
MHDA- 2020/02/20 06:00
CRDT- 2018/12/14 06:00
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2020/02/20 06:00 [medline]
PHST- 2018/12/14 06:00 [entrez]
AID - 10.1021/acs.jproteome.8b00290 [doi]
PST - ppublish
SO  - J Proteome Res. 2019 Jan 4;18(1):48-56. doi: 10.1021/acs.jproteome.8b00290. Epub 
      2018 Dec 13.