PMID- 30545606
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200113
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 222
IP  - 2
DP  - 2019 Mar
TI  - Associations of greenness with diabetes mellitus and glucose-homeostasis markers: 
      The 33 Communities Chinese Health Study.
PG  - 283-290
LID - S1438-4639(18)30760-0 [pii]
LID - 10.1016/j.ijheh.2018.12.001 [doi]
AB  - BACKGROUND: Residing in greener places may be protective against diabetes 
      mellitus (DM) but evidence is scarce and comes mainly from developed countries. 
      OBJECTIVES: To investigate associations of residential greenness with DM 
      prevalence and glucose-homeostasis markers in Chinese adults and whether these 
      associations were mediated by air pollution, physical activity, and body mass 
      index. METHODS: In 2009, a total of 15,477 adults from the cross-sectional 33 
      Communities Chinese Health Study provided blood samples and completed a 
      questionnaire. We considered fasting and 2-h glucose and insulin concentrations, 
      as well as the homoeostasis model assessment of insulin resistance and beta-cell 
      function, as glucose-homeostasis markers. DM was defined according to the 
      American Diabetes Association's recommendations. Residential greenness was 
      estimated by two satellite-derived vegetation indexes - Normalized Difference 
      Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI). Nitrogen 
      dioxide and particulate matter </=2.5 mum were used as air pollution proxies. 
      Associations were assessed by two-level adjusted logistic and linear regression 
      models. RESULTS: A 0.1-unit increase in NDVI(500 m) and SAVI(500 m) was 
      significantly associated with lower odds of DM by factors of 0.88 (95% Confidence 
      Interval 0.82-0.94) and 0.80 (0.72-0.90), respectively. Higher greenness was also 
      significantly associated with lower fasting and 2-h glucose levels, 2-h insulin 
      level, as well as lower insulin resistance and higher beta-cell function. Air 
      pollution and body mass index significantly mediated 6.9-51.1% and 8.6-78.7% 
      these associations, respectively, while no mediation role was observed for 
      physical activity. CONCLUSIONS: Higher residential greenness appears to be 
      associated with a lower prevalence of DM. This association might be due to 
      glucose and insulin metabolism and pancreatic beta-cell function. Lower levels of 
      air pollution and body mass index can be pathways linking greenspace to diabetes.
CI  - Copyright (c) 2018. Published by Elsevier GmbH.
FAU - Yang, Bo-Yi
AU  - Yang BY
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Preventive Medicine, School of Public 
      Health, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Markevych, Iana
AU  - Markevych I
AD  - Institute and Clinic for Occupational, Social and Environmental Medicine, 
      University Hospital, LMU Munich, Ziemssenstrasse 1, 80336, Munich, Germany; 
      Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for 
      Environmental Health, Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany; 
      Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's 
      Hospital, Munich, Ludwig Maximilian University of Munich, Munich, Germany.
FAU - Heinrich, Joachim
AU  - Heinrich J
AD  - Institute and Clinic for Occupational, Social and Environmental Medicine, 
      University Hospital, LMU Munich, Ziemssenstrasse 1, 80336, Munich, Germany; 
      Comprehensive Pneumology Center Munich, German Center for Lung Research, 
      Ziemssenstrasse 1, 80336, Munich, Germany.
FAU - Bowatte, Gayan
AU  - Bowatte G
AD  - Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School 
      of Population & Global Health, The University of Melbourne, Melbourne, VIC, 3010, 
      Australia; National Institute of Fundamental Studies, Kandy, 20000, Sri Lanka.
FAU - Bloom, Michael S
AU  - Bloom MS
AD  - Department of Environmental Health Sciences, University at Albany, State 
      University of New York, Rensselaer, NY, 12144, USA; Department of Epidemiology 
      and Biostatics, University at Albany, State University of New York, Rensselaer, 
      NY, 12144, USA.
FAU - Guo, Yuming
AU  - Guo Y
AD  - Department of Epidemiology and Preventive Medicine, School of Public Health and 
      Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
FAU - Dharmage, Shyamali C
AU  - Dharmage SC
AD  - Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School 
      of Population & Global Health, The University of Melbourne, Melbourne, VIC, 3010, 
      Australia; Murdoch Children Research Institute, Melbourne, VIC, 3010, Australia.
FAU - Jalaludin, Bin
AU  - Jalaludin B
AD  - Centre for Air Quality and Health Research and Evaluation, Glebe, NSW, 2037, 
      Australia; Population Health, South Western Sydney Local Health District, 
      Liverpool, NSW, 2170, Australia; Ingham Institute for Applied Medical Research, 
      Liverpool, NSW, 2170, Australia; School of Public Health and Community Medicine, 
      The University of New South Wales, Kensington, NSW, 2052, Australia.
FAU - Knibbs, Luke D
AU  - Knibbs LD
AD  - School of Public Health, The University of Queensland, Herston, Queensland, 4006, 
      Australia.
FAU - Morawska, Lidia
AU  - Morawska L
AD  - International Laboratory for Air Quality and Health, Queensland University of 
      Technology (QUT), GPO Box 2434, Brisbane, Queensland, 4001, Australia.
FAU - Qian, Zhengmin Min
AU  - Qian ZM
AD  - Department of Epidemiology, College for Public Health and Social Justice, Saint 
      Louis University, Saint Louis, 63104, USA.
FAU - Chen, Duo-Hong
AU  - Chen DH
AD  - Department of Air Quality Forecasting and Early Warning, Guangdong Environmental 
      Monitoring Center, State Environmental Protection Key Laboratory of Regional Air 
      Quality Monitoring, Guangdong Environmental Protection Key Laboratory of 
      Atmospheric Secondary Pollution, Guangzhou, 510308, China.
FAU - Ma, Huimin
AU  - Ma H
AD  - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of 
      Environmental Protection and Resources Utilization, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.
FAU - Chen, Da
AU  - Chen D
AD  - School of Environment, Guangzhou Key Laboratory of Environmental Exposure and 
      Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan 
      University, Guangzhou, 510632, China.
FAU - Lin, Shao
AU  - Lin S
AD  - Department of Environmental Health Sciences, University at Albany, State 
      University of New York, Rensselaer, NY, 12144, USA; Department of Epidemiology 
      and Biostatics, University at Albany, State University of New York, Rensselaer, 
      NY, 12144, USA.
FAU - Yang, Mo
AU  - Yang M
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Preventive Medicine, School of Public 
      Health, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Liu, Kang-Kang
AU  - Liu KK
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Preventive Medicine, School of Public 
      Health, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Zeng, Xiao-Wen
AU  - Zeng XW
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Preventive Medicine, School of Public 
      Health, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Hu, Li-Wen
AU  - Hu LW
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Preventive Medicine, School of Public 
      Health, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Preventive Medicine, School of Public 
      Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: 
      donggh5@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181210
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Air Pollutants)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Particulate Matter)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Adult
MH  - Air Pollutants/analysis
MH  - Blood Glucose/analysis
MH  - China/epidemiology
MH  - Diabetes Mellitus/blood/*epidemiology
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Nitrogen Dioxide/analysis
MH  - Particulate Matter/analysis
MH  - *Plants
MH  - *Residence Characteristics
MH  - Satellite Imagery
OTO - NOTNLM
OT  - Cross-sectional
OT  - Diabetes mellitus
OT  - Glucose
OT  - Greenness
OT  - Insulin resistance
OT  - Mediation
EDAT- 2018/12/14 06:00
MHDA- 2020/01/14 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/09/06 00:00 [received]
PHST- 2018/11/24 00:00 [revised]
PHST- 2018/12/02 00:00 [accepted]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - S1438-4639(18)30760-0 [pii]
AID - 10.1016/j.ijheh.2018.12.001 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2019 Mar;222(2):283-290. doi: 
      10.1016/j.ijheh.2018.12.001. Epub 2018 Dec 10.