PMID- 30545733
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20190916
IS  - 1464-3391 (Electronic)
IS  - 0968-0896 (Linking)
VI  - 27
IP  - 2
DP  - 2019 Jan 15
TI  - Stability and properties of Z-DNA containing artificial nucleobase 
      2'-O-methyl-8-methyl guanosine.
PG  - 364-369
LID - S0968-0896(18)31790-5 [pii]
LID - 10.1016/j.bmc.2018.12.005 [doi]
AB  - We synthesized several DNA oligonucleotides containing one or several 
      2'-O-methyl-8-methyl guanosine (m(8)Gm) and demonstrated that these 
      oligonucleotides not only stabilize the Z-DNA with a wide range of sequences 
      under low salt conditions but also possess high thermal stability. Using 
      artificial nucleobase-containing oligonucleotides, we studied the interaction of 
      the Zalpha domain with Z-DNA. Furthermore, we showed that the m(8)Gm-contained 
      oligonucleotides allow to study the photochemical reaction of Z-DNA.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Balasubramaniyam, Thananjeyan
AU  - Balasubramaniyam T
AD  - Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyo-take, Miyazaki 889-1692, Japan.
FAU - Ishizuka, Takumi
AU  - Ishizuka T
AD  - Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyo-take, Miyazaki 889-1692, Japan.
FAU - Xu, Yan
AU  - Xu Y
AD  - Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyo-take, Miyazaki 889-1692, Japan. 
      Electronic address: xuyan@med.miyazaki-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181206
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (DNA, Z-Form)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (enhanced green fluorescent protein)
RN  - 12133JR80S (Guanosine)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - DNA, Z-Form/chemical synthesis/*chemistry/metabolism/radiation effects
MH  - Green Fluorescent Proteins/metabolism
MH  - Guanosine/*analogs & derivatives/*chemistry
MH  - Oligodeoxyribonucleotides/chemical synthesis/*chemistry/metabolism/radiation 
      effects
MH  - Oxidation-Reduction
MH  - Protein Binding
MH  - Transition Temperature
MH  - Ultraviolet Rays
OTO - NOTNLM
OT  - Artificial nucleobase
OT  - Circular dichroism
OT  - Interaction of protein and Z-DNA
OT  - Photochemical reaction
OT  - Z-DNA oligonucleotide
EDAT- 2018/12/14 06:00
MHDA- 2019/09/17 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/10/18 00:00 [received]
PHST- 2018/12/04 00:00 [revised]
PHST- 2018/12/05 00:00 [accepted]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - S0968-0896(18)31790-5 [pii]
AID - 10.1016/j.bmc.2018.12.005 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2019 Jan 15;27(2):364-369. doi: 10.1016/j.bmc.2018.12.005. Epub 
      2018 Dec 6.