PMID- 30546049
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20240405
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Dec 13
TI  - Two-frame apparent motion presented with an inter-stimulus interval reverses 
      optokinetic responses in mice.
PG  - 17816
LID - 10.1038/s41598-018-36260-z [doi]
LID - 17816
AB  - Two successive image frames presented with a blank inter-stimulus interval (ISI) 
      induce reversals of perceived motion in humans. This illusory effect is a 
      manifestation of the temporal properties of image filters embedded in the visual 
      processing pathway. In the present study, ISI experiments were performed to 
      identify the temporal characteristics of vision underlying optokinetic responses 
      (OKRs) in mice. These responses are thought to be mediated by subcortical visual 
      processing. OKRs of C57BL/6 J mice, induced by a 1/4-wavelength shift of a 
      square-wave grating presented with and without an ISI were recorded. When a 
      1/4-wavelength shift was presented without, or with shorter ISIs (</=106.7 ms), 
      OKRs were induced in the direction of the shift, with progressively decreasing 
      amplitude as the ISI increased. However, when ISIs were 213.3 ms or longer, OKR 
      direction reversed. Similar dependence on ISIs was also obtained using a 
      sinusoidal grating. We subsequently quantitatively estimated temporal filters 
      based on the ISI effects. We found that filters with biphasic impulse response 
      functions could reproduce the ISI and temporal frequency dependence of the mouse 
      OKR. Comparison with human psychophysics and behaviors suggests that mouse vision 
      has more sluggish response dynamics to light signals than that of humans.
FAU - Miura, Kenichiro
AU  - Miura K
AD  - Department of Integrative Brain Science, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan. kmiura@brain.med.kyoto-u.ac.jp.
FAU - Sugita, Yuko
AU  - Sugita Y
AD  - Department of Integrative Brain Science, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
AD  - Laboratory for Molecular and Developmental Biology, Institute for Protein 
      Research, Osaka University, Osaka, Japan.
FAU - Furukawa, Takahisa
AU  - Furukawa T
AD  - Laboratory for Molecular and Developmental Biology, Institute for Protein 
      Research, Osaka University, Osaka, Japan.
FAU - Kawano, Kenji
AU  - Kawano K
AD  - Department of Integrative Brain Science, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181213
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - Humans
MH  - Male
MH  - Mice
MH  - Motion Perception/*physiology
MH  - Nystagmus, Optokinetic/*physiology
PMC - PMC6292883
COIS- The authors declare no competing interests.
EDAT- 2018/12/14 06:00
MHDA- 2019/10/23 06:00
PMCR- 2018/12/13
CRDT- 2018/12/15 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2018/11/19 00:00 [accepted]
PHST- 2018/12/15 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/12/13 00:00 [pmc-release]
AID - 10.1038/s41598-018-36260-z [pii]
AID - 36260 [pii]
AID - 10.1038/s41598-018-36260-z [doi]
PST - epublish
SO  - Sci Rep. 2018 Dec 13;8(1):17816. doi: 10.1038/s41598-018-36260-z.