PMID- 30546392
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 16
IP  - 6
DP  - 2018 Dec
TI  - Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of 
      food allergies in mice.
PG  - 4445-4456
LID - 10.3892/etm.2018.6763 [doi]
AB  - Food allergy prevalence has steadily increased worldwide over the past decades 
      and immunotherapeutic treatment strategies are gaining attention. Human umbilical 
      cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory 
      properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer 
      ethical constraints and are potential candidates for allergic disorder therapies. 
      The current study aimed to investigate potential antiallergic properties of 
      hUC-MSCs in mice with ovalbumin (OVA)-induced food allergy. Administration of 
      hUC-MSCs cells intraperitoneally combined with oral gavage of the culture medium 
      significantly alleviated OVA-induced diarrhea symptoms. Additionally, this 
      treatment significantly decreased IgE levels and the percentage of T helper 2 
      cells in the blood, which were increased in mice with OVA-induced food allergy. 
      The mRNA levels of the inflammatory cytokines interleukin-4 and tumor necrosis 
      factor-alpha, and inflammatory cell infiltration in mouse colons were significantly 
      decreased in hUC-MSCs-treated animals compared with mice with OVA-induced food 
      allergy. Goblet cells were detected in colons of allergy-induced mice and their 
      numbers were reduced following treatment with hUC-MSCs. In addition, treatment 
      with hUC-MSCs reestablished the gut flora. The results revealed that hUC-MSCs may 
      have a potential application in food allergy therapy.
FAU - Yan, Nannan
AU  - Yan N
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Xu, Jie
AU  - Xu J
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Zhao, Chuanxiang
AU  - Zhao C
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Wu, Yi
AU  - Wu Y
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Gao, Fengwei
AU  - Gao F
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Li, Ci
AU  - Li C
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Zhou, Wenhui
AU  - Zhou W
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Xiao, Tengfei
AU  - Xiao T
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Zhou, Xiaoming
AU  - Zhou X
AD  - Department of Pathology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
FAU - Shao, Qixiang
AU  - Shao Q
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Xia, Sheng
AU  - Xia S
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
AD  - Institute of Clinic Laboratory Diagnostic, School of Medicine, Jiangsu 
      University, Zhenjiang, Jiangsu 212013, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180919
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6256969
OTO - NOTNLM
OT  - IgE
OT  - T helper 2 cell
OT  - colon
OT  - food allergy
OT  - immunotherapy
OT  - mesenchymal stem cell
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/09/19
CRDT- 2018/12/15 06:00
PHST- 2018/01/03 00:00 [received]
PHST- 2018/08/09 00:00 [accepted]
PHST- 2018/12/15 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/09/19 00:00 [pmc-release]
AID - ETM-0-0-6763 [pii]
AID - 10.3892/etm.2018.6763 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Dec;16(6):4445-4456. doi: 10.3892/etm.2018.6763. Epub 2018 Sep 
      19.