PMID- 30546882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 9
IP  - 6
DP  - 2018 Dec
TI  - Distinct HLA class I and II genotypes and haplotypes are associated with multiple 
      sclerosis in Bahrain.
PG  - 531-539
LID - 10.3892/br.2018.1164 [doi]
AB  - Multiple sclerosis (MS) has become prevalent in the Arabian Gulf area with high 
      incidence in Bahrain due to environmental influences and genetic 
      susceptibilities, but there is a lack of study into human leukocyte antigen (HLA) 
      types in patients with MS in Bahrain. The present study aimed to study the HLA 
      types expressed in MS patients compared with in control subjects. Blood samples 
      from 50 Bahraini patients with MS and 50 Bahraini control subjects' were 
      subjected to HLA tissue typing by polymerase chain reaction using 
      sequence-specific primers. In comparison with those in control subjects, the 
      allele frequencies of HLA class-I antigens A2, A9, A19, B5, B35 and B40 were 
      higher in MS patients. For class II antigens, the allele frequencies of DR3, DR4 
      and DR16 were higher in MS patients. The allele frequency of DR15 was lower in MS 
      patients than in control subjects but the difference was not statistically 
      significant (P=0.138). The higher prevalence of the HLA-ABDR allele was common 
      among the female patients with MS, in relapse remission stage, in cases with 
      higher expanded disability status scale scores and with disease duration between 
      4 and 9 years. Haplotype HLA-A2-B40-DR2 exhibited significantly higher frequency 
      in MS patients compared with in control subjects (P=0.03). In conclusion, the 
      results indicated different alleles associated with MS compared with previous 
      reviews. The present study supports the importance of identifying genetic 
      susceptibilities and targets for therapies in specific populations and 
      individuals, to personalize disease management in terms of prediction, protective 
      measures and treatment.
FAU - Al-Nashmi, Moudi
AU  - Al-Nashmi M
AD  - Department of Molecular Medicine, Princess Al-Jawhara Center for Genetics and 
      Inherited Diseases, Arabian Gulf University, Manama 329, Bahrain.
FAU - Taha, Safa
AU  - Taha S
AD  - Department of Molecular Medicine, Princess Al-Jawhara Center for Genetics and 
      Inherited Diseases, Arabian Gulf University, Manama 329, Bahrain.
FAU - Salem, Abdel Halim
AU  - Salem AH
AD  - Department of Anatomy, College of Medicine and Medical Sciences, Arabian Gulf 
      University, Manama 329, Bahrain.
FAU - Alsharoqi, Isa
AU  - Alsharoqi I
AD  - Department of Neuroscience, Salmaniya Medical Complex, Manama 12, Bahrain.
FAU - Bakhiet, Moiz
AU  - Bakhiet M
AD  - Department of Molecular Medicine, Princess Al-Jawhara Center for Genetics and 
      Inherited Diseases, Arabian Gulf University, Manama 329, Bahrain.
LA  - eng
PT  - Journal Article
DEP - 20181024
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC6256251
OTO - NOTNLM
OT  - alleles
OT  - expanded disability status scale
OT  - genes
OT  - human leukocyte antigen typing
OT  - multiple sclerosis
OT  - polymerase chain reaction
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/10/24
CRDT- 2018/12/15 06:00
PHST- 2018/05/03 00:00 [received]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2018/12/15 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/10/24 00:00 [pmc-release]
AID - BR-0-0-1164 [pii]
AID - 10.3892/br.2018.1164 [doi]
PST - ppublish
SO  - Biomed Rep. 2018 Dec;9(6):531-539. doi: 10.3892/br.2018.1164. Epub 2018 Oct 24.