PMID- 30548214
OWN - NLM
STAT- MEDLINE
DCOM- 20200131
LR  - 20220410
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 9
IP  - 4
DP  - 2019 Apr
TI  - Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a 
      nested case-control study using a national sample cohort.
PG  - 357-362
LID - 10.1002/alr.22259 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate the relations between 
      gastroesophageal reflux disease (GERD) and chronic rhinosinusitus (CRS) in a 
      Korean population. METHODS: Subjects from the Korean National Health Insurance 
      Service-National Sample Cohort, all >/=20 years old, were assessed from 2002 to 
      2013. In total, 23,489 CRS participants were matched with 93,956 controls at a 
      ratio of 1:4 with respect to age, group, sex, income group, region of residence, 
      hypertension, diabetes, and dyslipidemia. We analyzed previous history of GERD in 
      the CRS and control groups. The CRS group included patients identified using 
      International Classification of Diseases 10th edition (ICD-10) codes (J32) who 
      had treated their CRS >/=2 times and had undergone head and neck computed 
      tomography (CT). The GERD group included patients identified using the ICD-10 
      (K21) code who had treated their GERD >/=2 times and had taken a proton pump 
      inhibitor (PPI) for >/=2 weeks. Crude and adjusted odds ratios (ORs) were analyzed 
      using unconditional logistic regression analyses. The 95% confidence intervals 
      (CIs) were calculated. Subgroup analyses were performed according to age and sex. 
      RESULTS: The rate of GERD was higher in the CRS group (17.1% [4020 of 23,489]) 
      than in the control group (9.1% [8522 of 93,956]; p < 0.001). The adjusted OR of 
      GERD was 2.04 (95% CI, 1.96-2.13; p < 0.001) in the CRS group. The results of the 
      subgroup analyses were consistent. CONCLUSION: The ORs of GERD were increased in 
      CRS participants. This relationship was consistent in all age and sex groups.
CI  - (c) 2018 ARS-AAOA, LLC.
FAU - Kim, So Young
AU  - Kim SY
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical 
      Center, CHA University, Seongnam, Korea.
FAU - Park, Bumjung
AU  - Park B
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University 
      College of Medicine, Anyang, Korea.
FAU - Lim, Hyun
AU  - Lim H
AD  - Department of Internal Medicine, Hallym University College of Medicine, Anyang, 
      Korea.
FAU - Kim, Miyoung
AU  - Kim M
AD  - Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, 
      Korea.
FAU - Kong, Il Gyu
AU  - Kong IG
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University 
      College of Medicine, Anyang, Korea.
FAU - Choi, Hyo Geun
AU  - Choi HG
AUID- ORCID: 0000-0003-1655-9549
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University 
      College of Medicine, Anyang, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181210
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Female
MH  - Gastroesophageal Reflux/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Republic of Korea/epidemiology
MH  - Rhinitis/*epidemiology
MH  - Risk Factors
MH  - Sinusitis/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - cohort studies
OT  - epidemiology
OT  - gastroesophageal reflux
OT  - nested case-control studies
OT  - rhinitis
OT  - sinusitis
EDAT- 2018/12/15 06:00
MHDA- 2020/02/01 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/09/03 00:00 [received]
PHST- 2018/11/06 00:00 [revised]
PHST- 2018/11/13 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2020/02/01 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - 10.1002/alr.22259 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2019 Apr;9(4):357-362. doi: 10.1002/alr.22259. Epub 
      2018 Dec 10.