PMID- 30548476
OWN - NLM
STAT- MEDLINE
DCOM- 20191108
LR  - 20191108
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 59
IP  - 3
DP  - 2019 Mar
TI  - Susceptible and protective HLA-DR and HLA-DQ alleles for Fy(a) alloimmunization 
      in the Croatian population.
PG  - 1118-1124
LID - 10.1111/trf.15087 [doi]
AB  - BACKGROUND: Alloimmunization is a known risk of transfusion therapy caused by 
      exposure to foreign RBC antigens. However, alloimmunization is not observed in 
      all transfused patients. Human leukocyte antigen (HLA) molecules may contribute 
      to the recognition and presentation of foreign antigens and to the potency of 
      immune responses that result in the production of antibodies. The aim of this 
      study was to determine the association of HLA-DR and HLA-DQ polymorphisms with 
      alloimunization to Fy(a) antigen in Croatian patients. STUDY DESIGN AND METHODS: 
      The study was conducted on 70 alloimmunized patients to Fy(a) antigen and two 
      control groups: 165 healthy Croatian individuals (Control 1) and 45 Fy(a) 
      antigen-negative nonimmunized patients exposed to Fy(a) antigen (Control 2). 
      Phenotype frequencies for HLA-DRB1 and HLA-DQB1 alleles were compared between the 
      cases and control groups. RESULTS: Statistically significant differences in 
      phenotype frequencies between cases and controls were found for DRB1*04 (odds 
      ratios [ORs], 10.5 and 18.7 for Control 1 and Control 2, respectively), DRB1*15 
      (ORs, 8.0 and 6.9), and DQB1*02 alleles (ORs, 0.2 and 0.03); and 
      DRB1*04-DQB1*03:01 (ORs, 7.9 and 17.6), DRB1*04-DQB1*03:02 (ORs, 5.5 and 7.6), 
      DRB1*15-DQB1*06:02 (ORs, 7.3 and 5.5), DRB1*03-DQB1*02:01 (OR, 0.1), and 
      DRB1*07-DQB1*02:02 (OR, 0.3) haplotypes. CONCLUSION: Several HLA-DRB1 and 
      HLA-DQB1 alleles and haplotypes were proved to contribute to and protect from 
      alloimmunization to Fy(a) antigens. Alleles DRB1*04 and DRB1*15, as well as 
      haplotypes DRB1*04-DQB1*03:02 and DRB1*15-DQB1*06:02 can be considered as risk 
      factors, while allele DQB1*02 and haplotype DRB1*03-DQB1*02:01 have a protective 
      role in Fy(a) alloimmunization.
CI  - (c) 2018 AABB.
FAU - Raos, Mirela
AU  - Raos M
AD  - Clinical Department of Transfusion Medicine and Transplantation Biology, 
      University Hospital Center Zagreb, Zagreb, Croatia.
FAU - Zunec, Renata
AU  - Zunec R
AD  - Clinical Department of Transfusion Medicine and Transplantation Biology, 
      University Hospital Center Zagreb, Zagreb, Croatia.
FAU - Mocibob, Marko
AU  - Mocibob M
AD  - Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, 
      Croatia.
FAU - Gojceta, Koraljka
AU  - Gojceta K
AD  - Clinical Department of Transfusion Medicine and Transplantation Biology, 
      University Hospital Center Zagreb, Zagreb, Croatia.
FAU - Lukic, Marija
AU  - Lukic M
AD  - Clinical Department of Transfusion Medicine and Transplantation Biology, 
      University Hospital Center Zagreb, Zagreb, Croatia.
FAU - Golubic Cepulic, Branka
AU  - Golubic Cepulic B
AD  - Clinical Department of Transfusion Medicine and Transplantation Biology, 
      University Hospital Center Zagreb, Zagreb, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20181212
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Croatia
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains/genetics/immunology
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/genetics
EDAT- 2018/12/15 06:00
MHDA- 2019/11/09 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/10/11 00:00 [revised]
PHST- 2018/10/30 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2019/11/09 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - 10.1111/trf.15087 [doi]
PST - ppublish
SO  - Transfusion. 2019 Mar;59(3):1118-1124. doi: 10.1111/trf.15087. Epub 2018 Dec 12.