PMID- 30548484
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Print)
IS  - 1043-3074 (Linking)
VI  - 41
IP  - 2
DP  - 2019 Feb
TI  - Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma.
PG  - 423-428
LID - 10.1002/hed.25444 [doi]
AB  - BACKGROUND: We sought to describe targeted DNA sequencing data of 
      persistent/recurrent laryngeal squamous cell carcinoma (LSCC) and to compare 
      gene-specific alteration frequencies with that of primary, untreated LSCC 
      specimens from The Cancer Genome Atlas (TCGA). METHODS: The tumors of 21 patients 
      with persistent/recurrent LSCC were subjected to targeted DNA sequencing using 
      the Ion AmpliSeq Comprehensive Cancer Panel. Gene-specific alteration frequencies 
      were compared (Chi-Square test) to primary, untreated LSCC sequencing data from 
      TCGA using the cBioPortal platform. RESULTS: Persistent/recurrent LSCC was 
      characterized by a high rate of inactivating alterations in TP53 (38.1%) and 
      CDKN2A (33%), amplification events of CCND1 (19.1%), and ERBB2 (14.3%), and 
      NOTCH1 (19.1%) mutations. Comparison of primary vs persistent/recurrent LSCC 
      revealed significant differences in alteration frequencies of eight critical 
      genes: BAP1, CDKN2A, DCUN1D1, MSH2, MTOR, PIK3CA, TET2, and TP53. CONCLUSIONS: 
      Our results provide preliminary support for a distinct mutational profile of 
      persistent/recurrent LSCC that requires validation in larger cohorts.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Smith, Joshua D
AU  - Smith JD
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Birkeland, Andrew C
AU  - Birkeland AC
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Rosko, Andrew J
AU  - Rosko AJ
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Hoesli, Rebecca C
AU  - Hoesli RC
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Foltin, Susan K
AU  - Foltin SK
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Swiecicki, Paul
AU  - Swiecicki P
AD  - Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann 
      Arbor, Michigan.
AD  - Department of Internal Medicine, Division of Hematology and Oncology, University 
      of Michigan Medical School, Ann Arbor, Michigan.
FAU - Mierzwa, Michelle
AU  - Mierzwa M
AD  - Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann 
      Arbor, Michigan.
AD  - Department of Radiation Oncology, University of Michigan Medical School, Ann 
      Arbor, Michigan.
FAU - Chinn, Steven B
AU  - Chinn SB
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Shuman, Andrew G
AU  - Shuman AG
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Malloy, Kelly M
AU  - Malloy KM
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Casper, Keith A
AU  - Casper KA
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - McLean, Scott A
AU  - McLean SA
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Wolf, Gregory T
AU  - Wolf GT
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
FAU - Bradford, Carol R
AU  - Bradford CR
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
AD  - Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann 
      Arbor, Michigan.
FAU - Prince, Mark E
AU  - Prince ME
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
AD  - Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann 
      Arbor, Michigan.
FAU - Brenner, John Chad
AU  - Brenner JC
AUID- ORCID: 0000-0003-3238-1111
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
AD  - Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann 
      Arbor, Michigan.
AD  - Program in Cellular and Molecular Biology, University of Michigan Medical School, 
      Ann Arbor, Michigan.
AD  - Department of Pharmacology, University of Michigan Medical School, Ann Arbor, 
      Michigan.
FAU - Spector, Matthew E
AU  - Spector ME
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, Michigan.
AD  - Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann 
      Arbor, Michigan.
LA  - eng
GR  - P30-CA046592R01-CA194536T32 DC535615U01-DE025184/NH/NIH HHS/United States
GR  - P50 CA097248/CA/NCI NIH HHS/United States
GR  - U01 DE025184/DE/NIDCR NIH HHS/United States
GR  - P30 CA046592/CA/NCI NIH HHS/United States
GR  - R01-CA194536/NH/NIH HHS/United States
GR  - R01 CA194536/CA/NCI NIH HHS/United States
GR  - T32 DC005356/DC/NIDCD NIH HHS/United States
GR  - U01-DE025184/NH/NIH HHS/United States
GR  - American Head and Neck Society/International
GR  - T32 DC535615/NH/NIH HHS/United States
GR  - P30-CA046592/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181212
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics/pathology/therapy
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Mutation/*genetics
MH  - Neoplasm Recurrence, Local/*genetics/mortality/pathology
MH  - Survival Rate
PMC - PMC6431792
MID - NIHMS992882
OTO - NOTNLM
OT  - TCGA
OT  - laryngeal squamous cell carcinoma
OT  - larynx
OT  - persistent
OT  - recurrent
EDAT- 2018/12/15 06:00
MHDA- 2020/09/10 06:00
PMCR- 2020/02/01
CRDT- 2018/12/15 06:00
PHST- 2018/04/22 00:00 [received]
PHST- 2018/06/22 00:00 [revised]
PHST- 2018/09/06 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - 10.1002/hed.25444 [doi]
PST - ppublish
SO  - Head Neck. 2019 Feb;41(2):423-428. doi: 10.1002/hed.25444. Epub 2018 Dec 12.