PMID- 30549356
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 41
IP  - 2
DP  - 2019 Feb
TI  - Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: 
      Potential markers for malignant transformation of recurrent respiratory 
      papillomatosis and for prognosis of laryngeal cancer.
PG  - 309-314
LID - 10.1002/hed.25459 [doi]
AB  - BACKGROUND: Biomarkers that could predict malignant transformation of recurrent 
      respiratory papillomatosis (RRP) would be useful in patient follow-up. We 
      investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue 
      inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation 
      of RRP and whether they associate with survival in laryngeal squamous cell 
      carcinoma (LSCC) without preexisting RRP. METHODS: We analyzed serum MMP-8 
      (S-MMP-8) and serum TIMP-1 (s-TIMP-1) in 114 patients: 55 were treated for RRP 
      and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC 
      during follow-up. RESULTS: Elevated S-MMP-8 level in RRP was associated with 
      malignant transformation (P = .01). Compared to patients with RRP, S-MMP-8 in 
      patients with LSCC was significantly higher (P < .001). Increased S-TIMP-1 level 
      in LSCC was associated with poor overall survival (P = .02) and recurrence-free 
      survival (P = .05). CONCLUSION: In RRP, high S-MMP-8 may predict malignant 
      transformation. In LSCC, elevated S-TIMP-1 is connected to poor survival.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Pakkanen, Pihla P
AU  - Pakkanen PP
AUID- ORCID: 0000-0002-0009-8146
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
FAU - Aaltonen, Leena-Maija
AU  - Aaltonen LM
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
FAU - Sorsa, Timo A
AU  - Sorsa TA
AD  - Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, 
      Finland.
AD  - Department of Dental Medicine, Karolinska Institutet and Karolinska University 
      Hospital, Huddinge, Stockholm, Sweden.
FAU - Tervahartiala, Taina I
AU  - Tervahartiala TI
AD  - Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, 
      Finland.
FAU - Hagstrom, Jaana K
AU  - Hagstrom JK
AD  - Department of Pathology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Ilmarinen, Taru T
AU  - Ilmarinen TT
AUID- ORCID: 0000-0001-8674-6417
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
LA  - eng
GR  - Helsinki University Hospital/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181214
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Biomarkers)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.34 (MMP8 protein, human)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
RN  - Recurrent respiratory papillomatosis
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Carcinoma, Squamous Cell/*blood/etiology/mortality
MH  - Cell Transformation, Neoplastic
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*blood/etiology/mortality
MH  - Male
MH  - Matrix Metalloproteinase 8/*blood
MH  - Middle Aged
MH  - Papillomavirus Infections/*blood/mortality/*pathology
MH  - Predictive Value of Tests
MH  - Respiratory Tract Infections/*blood/mortality/*pathology
MH  - Survival Rate
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood
OTO - NOTNLM
OT  - MMP-8
OT  - TIMP-1
OT  - biomarkers
OT  - laryngeal carcinoma
OT  - recurrent respiratory papilloma
EDAT- 2018/12/15 06:00
MHDA- 2020/09/10 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/01/07 00:00 [received]
PHST- 2018/06/13 00:00 [revised]
PHST- 2018/08/15 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - 10.1002/hed.25459 [doi]
PST - ppublish
SO  - Head Neck. 2019 Feb;41(2):309-314. doi: 10.1002/hed.25459. Epub 2018 Dec 14.