PMID- 30549443
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20191217
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 124
IP  - 6
DP  - 2019 Jun
TI  - Synergistic effects of prenatal nicotine exposure and post-weaning high-fat diet 
      on hypercholesterolaemia in rat offspring of different sexes.
PG  - 730-740
LID - 10.1111/bcpt.13187 [doi]
AB  - Hypercholesterolaemia is considered a disease with intrauterine origin. Recently, 
      we reported that prenatal nicotine exposure (PNE) induced an abnormal level of 
      total cholesterol in rat offspring before and after birth. However, there were 
      little data about sex differences in serum cholesterol level in PNE offspring. In 
      addition, many previous studies reported that blood cholesterol is associated 
      with daily diet. This study was designed to analyse the interaction among PNE, 
      high-fat diet (HFD) and sex on cholesterol metabolism in the rat. Pregnant Wistar 
      rats were administered 2 mg/kg nicotine subcutaneously from gestational day (GD) 
      11 until parturition. After weaning, pups were fed with normal diet or HFD till 
      24 weeks, and then, serum cholesterol phenotypes and hepatic cholesterol 
      metabolism-related genes were tested. Results showed that PNE manifested a 
      distinct programming effect on cholesterol phenotype and cholesterol 
      metabolism-related genes. HFD aggregated PNE-induced hypercholesterolaemia in 
      adult offspring and exacerbated liver cholesterol metabolism dysfunction in PNE 
      offspring. There was no sex difference in serum cholesterol level, but there were 
      interactions among PNE, HFD and sex on cholesterol metabolic genes in adult 
      offspring, which indicates that cholesterol metabolism in female offspring is 
      more likely to be affected by PNE and HFD. In conclusion, HFD exacerbated 
      PNE-induced hypercholesterolaemia, and sex differences existed in liver 
      cholesterol metabolic genes in PNE- or HFD-treated offspring.
CI  - (c) 2018 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society).
FAU - Zhu, Chunyan
AU  - Zhu C
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan China.
FAU - Guo, Yu
AU  - Guo Y
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan China.
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 
      China.
FAU - Luo, Hanwen
AU  - Luo H
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan China.
AD  - Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 
      China.
FAU - Wu, Yimeng
AU  - Wu Y
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan China.
FAU - Magdalou, Jacques
AU  - Magdalou J
AD  - Faculte de Medicine, UMR 7561 CNRS-Universite de Lorraine, Vandoeuvre-les-Nancy, 
      France.
FAU - Chen, Liaobin
AU  - Chen L
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 
      China.
AD  - Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 
      China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan China.
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 
      China.
LA  - eng
GR  - 2017YFC1001300/National Key Research and Development Program of China/
GR  - 81220108026/National Natural Science Foundation of China/
GR  - 81430089/National Natural Science Foundation of China/
GR  - 81673524/National Natural Science Foundation of China/
GR  - 81773812/National Natural Science Foundation of China/
GR  - WJ2017C0003/Hubei Province Health and Family Planning Scientific Research 
      Project/
PT  - Journal Article
DEP - 20190110
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (RNA, Messenger)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Cholesterol/blood/*metabolism
MH  - Cholesterol, HDL/blood/drug effects
MH  - Cholesterol, LDL/blood/drug effects
MH  - *Diet, High-Fat
MH  - Female
MH  - Fetal Growth Retardation/metabolism
MH  - Hypercholesterolemia/*metabolism
MH  - Lipid Metabolism
MH  - Litter Size/drug effects
MH  - Male
MH  - Nicotine/*pharmacology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Weaning
OTO - NOTNLM
OT  - high-fat diet
OT  - hypercholesterolemia
OT  - liver cholesterol metabolism
OT  - pregnancy nicotine exposure
OT  - sex
EDAT- 2018/12/15 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/08/20 00:00 [received]
PHST- 2018/11/23 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - 10.1111/bcpt.13187 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2019 Jun;124(6):730-740. doi: 10.1111/bcpt.13187. 
      Epub 2019 Jan 10.