PMID- 30549470
OWN - NLM
STAT- MEDLINE
DCOM- 20190108
LR  - 20200225
IS  - 2092-9382 (Electronic)
IS  - 1011-8942 (Print)
IS  - 1011-8942 (Linking)
VI  - 32
IP  - 6
DP  - 2018 Dec
TI  - Relationship between Progressive Changes in Lamina Cribrosa Depth and 
      Deterioration of Visual Field Loss in Glaucomatous Eyes.
PG  - 470-477
LID - 10.3341/kjo.2018.0015 [doi]
AB  - PURPOSE: To investigate the relationship between the progression of visual field 
      (VF) loss and changes in lamina cribrosa depth (LCD) as determined by 
      spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in 
      patients with primary open angle glaucoma (POAG). METHODS: Data from 60 POAG 
      patients (mean follow-up, 3.5 +/- 0.7 years) were included in this retrospective 
      study. The LCD was measured in the optic disc image using SD-OCT enhanced depth 
      imaging scanning at each visit. Change in the LCD was considered to either 
      'increase' or 'decrease' when the differences between baseline and the latest two 
      consecutive follow-up visits were greater than the corresponding reproducibility 
      coefficient value (23.08 mum, as determined in a preliminary reproducibility 
      study). All participants were divided into three groups: increased LCD (ILCD), 
      decreased LCD (DLCD), and no LCD change (NLCD). The Early Manifest Glaucoma Trial 
      criteria were used to define VF deterioration. Kaplan-Meier survival analysis and 
      Cox's proportional hazard models were performed to explore the relationship 
      between VF progression and LCD change. RESULTS: Of the 60 eyes examined, 35.0% 
      (21 eyes), 28.3% (17 eyes), and 36.7% (22 eyes) were classified as the ILCD, 
      DLCD, and NLCD groups, respectively. Kaplan-Meier survival analysis showed a 
      greater cumulative probability of VF progression in the ILCD group than in the 
      NLCD (p < 0.001) or DLCD groups (p = 0.018). Increased LCD was identified as the 
      only risk factor for VF progression in the Cox proportional hazard models (hazard 
      ratio, 1.008; 95% confidence interval, 1.000 to 1.015; p = 0.047). CONCLUSIONS: 
      Increased LCD was associated with a greater possibility of VF progression. The 
      quantitative measurement of LCD changes, determined by SD-OCT, is a potential 
      biomarker for the prediction of VF deterioration in patients with POAG.
CI  - (c) 2018 The Korean Ophthalmological Society.
FAU - Kim, You Na
AU  - Kim YN
AD  - Department of Ophthalmology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Shin, Joong Won
AU  - Shin JW
AD  - Department of Ophthalmology, Gangneung Asan Hospital, University of Ulsan College 
      of Medicine, Gangneung, Korea.
FAU - Sung, Kyung Rim
AU  - Sung KR
AD  - Department of Ophthalmology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea. sungeye@gmail.com.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Korean J Ophthalmol
JT  - Korean journal of ophthalmology : KJO
JID - 8804513
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Vision Disorders/*diagnosis/physiopathology
MH  - Visual Fields/*physiology
PMC - PMC6288017
OTO - NOTNLM
OT  - Glaucoma
OT  - Lamina cribrosa
OT  - Optic disk
OT  - Optical coherence tomography
OT  - Visual fields
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/12/15 06:00
MHDA- 2019/01/09 06:00
PMCR- 2018/12/01
CRDT- 2018/12/15 06:00
PHST- 2018/01/29 00:00 [received]
PHST- 2018/04/02 00:00 [accepted]
PHST- 2018/12/15 06:00 [entrez]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2019/01/09 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 32.470 [pii]
AID - 10.3341/kjo.2018.0015 [doi]
PST - ppublish
SO  - Korean J Ophthalmol. 2018 Dec;32(6):470-477. doi: 10.3341/kjo.2018.0015.