PMID- 30549606
OWN - NLM
STAT- MEDLINE
DCOM- 20190607
LR  - 20211204
IS  - 1934-578X (Print)
IS  - 1555-9475 (Linking)
VI  - 11
IP  - 10
DP  - 2016 Oct
TI  - Effect of Angelica acutiloba Extract on Blood flow Regulation in Stroke-prone 
      Spontaneously Hypertensive Rats.
PG  - 1497-1498
AB  - Angelica acutiloba Kitagawa (Yamato Toki) is a herbal medicine known to exhibit 
      various health effects. In this study, we used a rat model to examine the effects 
      of two different Yamato Toki extracts on the blood flow response of the instep of 
      the hind paw. Twelve-week- old male stroke-prone spontaneously hypertensive rats 
      (SHRSP) were orally given 200 mg of a water extract of Yamato Toki (n=6), 200 mg 
      of an ethanol extract of Yamato Toki (n = 6), 30 mg/kg of nicardipine (n = 6) as 
      a positive control and saline (n = 6) as a negative control. Blood flow was 
      monitored continuously for 0, 1, 3, 6 and 24 hours after treatment. Rats given 
      200 mg of the ethanol extract of Yamato Toki demonstrated significantly greater 
      blood flow compared with control rats at I hour after treatment. An ethanol 
      extract of Yamato Toki from Nara administrated orally can increase blood flow in 
      SHRSP.
FAU - Negishi, Hiroko
AU  - Negishi H
FAU - Sugahama, Sari
AU  - Sugahama S
FAU - Kawakamia, Ayaka
AU  - Kawakamia A
FAU - Kondo, Junna
AU  - Kondo J
FAU - Nishigaki, Yuriko
AU  - Nishigaki Y
FAU - Yoshikawa, Masato
AU  - Yoshikawa M
FAU - Ueyama, Taketeru
AU  - Ueyama T
FAU - Ikeda, Katsumi
AU  - Ikeda K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nat Prod Commun
JT  - Natural product communications
JID - 101477873
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - B66F4574UG (angelicae sinensis extract)
RN  - CZ5312222S (Nicardipine)
SB  - IM
MH  - Angelica/*chemistry
MH  - Angelica sinensis
MH  - Animals
MH  - Antihypertensive Agents/pharmacology
MH  - Blood Pressure/drug effects
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Foot/blood supply
MH  - Heart Rate/drug effects
MH  - Hindlimb/blood supply
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Medicine, Kampo
MH  - Nicardipine/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Regional Blood Flow/*drug effects
EDAT- 2016/10/01 00:00
MHDA- 2016/10/01 00:01
CRDT- 2018/12/15 06:00
PHST- 2018/12/15 06:00 [entrez]
PHST- 2016/10/01 00:00 [pubmed]
PHST- 2016/10/01 00:01 [medline]
PST - ppublish
SO  - Nat Prod Commun. 2016 Oct;11(10):1497-1498.