PMID- 30550036
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1724-5990 (Electronic)
IS  - 0393-5590 (Linking)
VI  - 35
IP  - 6
DP  - 2018 Dec
TI  - [FSGS collapsing variant during anabolic steroid abuse: Case Report].
LID - 2018-vol6 [pii]
AB  - Anabolic Androgenic Steroids (AAS) is an hormone family whose use has 
      considerably increased among body-builders during the last decades. The AAS 
      abuse, especially associated with other drugs or nutritional supplements and 
      protein loads, may cause a variety of pathologies to several organs with a 
      mechanism related to dosage, timing and substance. The kidney is the main 
      metabolizer of these drugs and it can be acutely or chronically damaged with 
      ESKD. The literature reports some cases of Focal Segmental Glomerulosclerosis 
      (FSGS) in body-builders who abused of AAS. However, the link is not well 
      understood and limited to some case-studies. In this paper, we report the case of 
      a young body-builder who developed a FSGS collapsing variant with ESKD after 
      prolonged abuse of AAS and a strongly hyperproteic diet and other dietary 
      supplements. The patient underwent a genetic test because of the rapid and 
      irreversibile onset of ESKD. The test showed a gene mutation of ACTN4, 
      predisposing and causal of some genetic forms of FSGS. It was a very complex 
      case, caused by several factors. The mutant protein of ACTN4 gene makes most 
      vulnerable the cytoskeleton of the podocytes to external disturbances. That would 
      explain why in those patients where the mutation has occurred, only those 
      patients subject to "unfavorable environmental conditions", like the abuse of 
      AAS, can develop a disease.
CI  - Copyright by Societa Italiana di Nefrologia SIN, Rome, Italy.
FAU - Flachi, Marta
AU  - Flachi M
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
FAU - Menghi, Viola
AU  - Menghi V
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
AD  - Medicina Interna ISS Repubblica di San Marino.
FAU - Moschella, Maria Rita
AU  - Moschella MR
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
FAU - De Giovanni, Paola
AU  - De Giovanni P
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
FAU - Montevecchi, Marcello
AU  - Montevecchi M
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
FAU - Cerretani, Davide
AU  - Cerretani D
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
FAU - Grimaldi, Daniela
AU  - Grimaldi D
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
FAU - Baraldi, Olga
AU  - Baraldi O
AD  - UO Nefrologia Dialisi e Trapianto Policlinico S. Orsola-Malpighi Bologna.
FAU - Fabbrizio, Benedetta
AU  - Fabbrizio B
AD  - SSD di Diagnostica Istopatologica e Molecolare degli Organi solidi e del relativo 
      Trapianto Policlinico S. Orsola-Malpighi Bologna.
FAU - La Manna, Gaetano
AU  - La Manna G
AD  - UO Nefrologia Dialisi e Trapianto Policlinico S. Orsola-Malpighi Bologna.
FAU - Rigotti, Angelo
AU  - Rigotti A
AD  - UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
LA  - ita
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - G Ital Nefrol
JT  - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di 
      nefrologia
JID - 9426434
RN  - 0 (Dietary Proteins)
RN  - 0 (Testosterone Congeners)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Adult
MH  - Cardiomegaly/etiology
MH  - Dietary Proteins/adverse effects
MH  - Glomerulosclerosis, Focal Segmental/*chemically induced/pathology
MH  - Humans
MH  - Hypertrophy, Left Ventricular/etiology
MH  - Ibuprofen/adverse effects
MH  - Kidney Failure, Chronic/etiology
MH  - Kidney Glomerulus/*ultrastructure
MH  - Male
MH  - *Physical Conditioning, Human
MH  - Podocytes/ultrastructure
MH  - Substance-Related Disorders/*etiology/pathology
MH  - Testosterone Congeners/*adverse effects
OTO - NOTNLM
OT  - AAS
OT  - ESKD
OT  - anabolic androgenic steroids
OT  - end stage kidney disease
OT  - focal segmental glomerulosclerosis collapsing variant
EDAT- 2018/12/15 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/12/15 06:00 [entrez]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
AID - 35-6-2018-6 [pii]
PST - ppublish
SO  - G Ital Nefrol. 2018 Dec;35(6):2018-vol6.