PMID- 30550794
OWN - NLM
STAT- MEDLINE
DCOM- 20191227
LR  - 20191227
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 148
DP  - 2019 Apr
TI  - Nicotine enhances responding for conditioned reinforcement via alpha4beta2 nicotinic 
      acetylcholine receptors in the ventral tegmental area, but not the nucleus 
      accumbens or the prefrontal cortex.
PG  - 68-76
LID - S0028-3908(18)30440-4 [pii]
LID - 10.1016/j.neuropharm.2018.12.011 [doi]
AB  - Nicotine enhances the conditioned reinforcing properties of reward-paired cues. 
      We investigated the role of the ventral tegmental area (VTA), nucleus accumbens 
      (NAcc), and prelimbic (PrL) and infralimbic (IL) cortices in mediating this 
      enhancement. Male Long-Evans rats were implanted with bilateral guide cannulae 
      aimed at either the VTA, NAcc, PrL or IL cortex. Next, rats underwent 12 sessions 
      of Pavlovian conditioning. Each session consisted of 30 trials wherein a 5 s 
      conditioned stimulus (CS) was paired with water (0.05 ml). Tests of responding 
      for conditioned reinforcement were conducted during which presentation of the CS, 
      now acting as a conditioned reinforcer (CRf), was contingent upon pressing one of 
      two levers (CRf lever). Pressing the other lever had no consequences (NCRf 
      lever). To determine if nicotinic acetylcholine receptors (nAChRs) in the VTA, 
      NAcc, PrL cortex, or IL cortex mediate nicotine-enhanced responding for a CRf, 
      the alpha4beta2 nAChR antagonist Dihydro-Beta-Erythroidine (DHbetaE; 10 nmol/0.5 muL) was 
      infused into the respective areas prior to a systemic nicotine injection 
      (0.2 mg/kg; SC). DHbetaE infused into the VTA, NAcc, or IL cortex, but not PrL 
      cortex, attenuated nicotine-enhanced responding for a CRf. Next, to confirm that 
      nAChRs in the VTA, NAcc, or IL cortex mediate this enhancement, nicotine (8, 16, 
      or 32 nmol/0.5 muL) was infused into the respective areas. Nicotine infused into 
      the VTA, but not NAcc or IL cortex, enhanced responding for a CRf. These findings 
      suggest that nicotine primarily acts on alpha4beta2 nAChRs in the VTA to potentiate the 
      conditioned reinforcing properties of reward-related cues.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Tabbara, Rayane I
AU  - Tabbara RI
AD  - Section of Biopsychology and Campbell Family Mental Health Research Institute, 
      Centre for Addiction and Mental Health, 250 College St., M5T 1R8, Toronto, ON, 
      Canada; Department of Psychology, University of Toronto, 100 St. George St., M5S 
      3G3, Toronto, ON, Canada. Electronic address: rayane.tabbara@mail.utoronto.ca.
FAU - Fletcher, Paul J
AU  - Fletcher PJ
AD  - Section of Biopsychology and Campbell Family Mental Health Research Institute, 
      Centre for Addiction and Mental Health, 250 College St., M5T 1R8, Toronto, ON, 
      Canada; Department of Psychology, University of Toronto, 100 St. George St., M5S 
      3G3, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, 250 
      College St., M5T 1R8, Toronto, ON, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181211
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Nicotinic Antagonists)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (nicotinic receptor alpha4beta2)
RN  - 23255-54-1 (Dihydro-beta-Erythroidine)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Conditioning, Classical/drug effects
MH  - Conditioning, Operant/drug effects/*physiology
MH  - Dihydro-beta-Erythroidine/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Nicotine/*pharmacology
MH  - Nicotinic Agonists/pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Rats
MH  - Receptors, Nicotinic/*physiology
MH  - Reinforcement, Psychology
MH  - Self Administration
MH  - Ventral Tegmental Area/drug effects/*physiology
OTO - NOTNLM
OT  - Infralimbic cortex
OT  - Nucleus accumbens
OT  - Prelimbic cortex
OT  - Rat
OT  - Reinforcement
OT  - Ventral tegmental area
EDAT- 2018/12/15 06:00
MHDA- 2019/12/28 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/07/30 00:00 [received]
PHST- 2018/12/04 00:00 [revised]
PHST- 2018/12/09 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2019/12/28 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - S0028-3908(18)30440-4 [pii]
AID - 10.1016/j.neuropharm.2018.12.011 [doi]
PST - ppublish
SO  - Neuropharmacology. 2019 Apr;148:68-76. doi: 10.1016/j.neuropharm.2018.12.011. 
      Epub 2018 Dec 11.