PMID- 30551263
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 34
IP  - 8
DP  - 2019 Aug
TI  - Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes 
      mellitus using transient elastography.
PG  - 1396-1403
LID - 10.1111/jgh.14577 [doi]
AB  - BACKGROUND AND AIM: The recommendation in regard to screening for non-alcoholic 
      fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients 
      differs in major guidelines. The aim of this paper was to study the prevalence of 
      NALFD and advanced fibrosis among T2DM patients. METHODS: This is a 
      cross-sectional study of consecutive adult T2DM patients attending the Diabetes 
      Clinic of a university hospital. Significant hepatic steatosis and advanced 
      fibrosis was diagnosed based on transient elastography if the controlled 
      attenuation parameter was >/= 263 dB/m, and the liver stiffness measurement was 
      >/= 9.6 kPa using the M probe or >/= 9.3 kPa using the XL probe, respectively. 
      Patients with liver stiffness measurement >/= 8 kPa were referred to the 
      Gastroenterology and Hepatology Clinic for further assessment, including liver 
      biopsy. RESULTS: The data of 557 patients were analyzed (mean age 
      61.4 +/- 10.8 years, male 40.6%). The prevalence of NAFLD and advanced fibrosis 
      based on transient elastography was 72.4% and 21.0%, respectively. On 
      multivariate analysis, independent factors associated with NAFLD were central 
      obesity (OR 4.856, 95% confidence interval [CI] 2.749-8.577, P = 0.006), serum 
      triglyceride (OR 1.585, 95% CI 1.056-2.381, P = 0.026), and alanine 
      aminotransferase levels (OR 1.047, 95% CI 1.025-1.070, P < 0.001) while advanced 
      fibrosis was associated with serum high-density lipoprotein cholesterol (OR 
      0.355, 95% CI 0.126-0.997, P = 0.049), alanine aminotransferase (OR 1.023, 95% CI 
      1.009-1.037, P = 0.001), gamma-glutamyltransferase (OR 1.005, 95% CI 1.001-1.008, 
      P = 0.017), and platelet levels (OR 0.995, 95% CI 0.992-0.999, P = 0.010). 
      Seventy-one patients underwent liver biopsy. The majority had non-alcoholic 
      steatohepatitis (83.1%) and >/= F1 fibrosis (87.3%) while advanced fibrosis was 
      seen in 36.6%. CONCLUSION: The prevalence of NAFLD and advanced fibrosis based on 
      transient elastography is high among T2DM patients.
CI  - (c) 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & 
      Sons Australia, Ltd.
FAU - Lai, Lee-Lee
AU  - Lai LL
AD  - Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of 
      Medicine, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Wan Yusoff, Wan Nur Illyana
AU  - Wan Yusoff WNI
AD  - Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of 
      Medicine, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Vethakkan, Shireene Ratna
AU  - Vethakkan SR
AD  - Endocrinology Unit, Department of Medicine, Faculty of Medicine, University of 
      Malaya, Kuala Lumpur, Malaysia.
FAU - Nik Mustapha, Nik Raihan
AU  - Nik Mustapha NR
AD  - Department of Pathology, Hospital Sultanah Bahiyah, Alor Setar, Malaysia.
FAU - Mahadeva, Sanjiv
AU  - Mahadeva S
AUID- ORCID: 0000-0001-5824-0590
AD  - Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of 
      Medicine, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Chan, Wah-Kheong
AU  - Chan WK
AUID- ORCID: 0000-0002-9105-5837
AD  - Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of 
      Medicine, University of Malaya, Kuala Lumpur, Malaysia.
LA  - eng
GR  - Project No.: BK006-2016/University of Malaya Special Research Fund/
GR  - Project No.: BKS067-2017/University of Malaya Special Research Fund/
GR  - BKS067-2017/University of Malaya Special Research Fund/
GR  - BK006-2016/University of Malaya Special Research Fund/
PT  - Journal Article
DEP - 20190121
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - *Elasticity Imaging Techniques
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis/*diagnostic imaging/*epidemiology
MH  - Malaysia/epidemiology
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*diagnostic imaging/*epidemiology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Risk Factors
OTO - NOTNLM
OT  - CAP
OT  - Fibroscan
OT  - LSM
OT  - NAFLD
OT  - NASH
OT  - T2DM
OT  - controlled attenuation parameter
OT  - liver fibrosis
OT  - liver stiffness measurement
EDAT- 2018/12/15 06:00
MHDA- 2020/02/11 06:00
CRDT- 2018/12/15 06:00
PHST- 2018/10/03 00:00 [received]
PHST- 2018/12/03 00:00 [revised]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2018/12/15 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2018/12/15 06:00 [entrez]
AID - 10.1111/jgh.14577 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2019 Aug;34(8):1396-1403. doi: 10.1111/jgh.14577. Epub 
      2019 Jan 21.