PMID- 30552619
OWN - NLM
STAT- MEDLINE
DCOM- 20191231
LR  - 20200309
IS  - 1559-0755 (Electronic)
IS  - 0257-277X (Linking)
VI  - 67
IP  - 1
DP  - 2019 Feb
TI  - FcRgamma deficiency improves survival in experimental sepsis by down-regulating TLR4 
      signaling pathway.
PG  - 77-83
LID - 10.1007/s12026-018-9039-y [doi]
AB  - Fc receptor common gamma signaling chain (FcRgamma), a common subunit shared by Fc 
      receptors (FcgammaRI, III, IV, FcalphaRI, and FcepsilonRI), is an important immune regulator 
      both in innate and adaptive immunity. Previous studies have shown that FcRgamma was a 
      potential target of inflammatory diseases, whereas the role of FcRgamma in sepsis has 
      been poorly understood. In this study, we found that deficiency of FcRgamma resulted 
      in increased survival in lipopolysaccharide (LPS)/D-galactosamine and E. 
      coli-induced sepsis in mice. This protective effect was characterized by 
      decreased TNF-alpha, IL-6, and IL-10. Further experiments in bone marrow-derived 
      macrophages (BMDMs) in vitro also showed that FcRgamma deficiency resulted in 
      decreased production of TNF-alpha, IL-6, and IL-10 upon LPS stimulation. The 
      mechanism study showed that FcRgamma was physiologically associated with toll-like 
      receptor 4 (TLR4), and tyrosine phosphorylation of FcRgamma mediated TLR4 signaling 
      pathway, followed by increased ERK phosphorylation upon LPS stimulation. Our 
      results suggest that FcRgamma might be a potential therapeutic target of sepsis.
FAU - Wei, Zhi-Min
AU  - Wei ZM
AD  - Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 
      100853, China.
FAU - Wang, Zhuo
AU  - Wang Z
AD  - State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation 
      and Research, China Pharmaceutical University, Nanjing, 211198, China.
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, 
      China.
FAU - Wan, Xiao-Jian
AU  - Wan XJ
AD  - Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, 
      Second Military Medical University, 800 Xiangyin Rd, Yangpu Qu, Shanghai, China.
FAU - Li, Xian-Jing
AU  - Li XJ
AD  - State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation 
      and Research, China Pharmaceutical University, Nanjing, 211198, China.
FAU - Li, Yi-Xing
AU  - Li YX
AD  - State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation 
      and Research, China Pharmaceutical University, Nanjing, 211198, China.
FAU - Bai, Yang
AU  - Bai Y
AD  - State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation 
      and Research, China Pharmaceutical University, Nanjing, 211198, China.
FAU - Yang, Xue
AU  - Yang X
AD  - State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation 
      and Research, China Pharmaceutical University, Nanjing, 211198, China.
FAU - Yang, Yong
AU  - Yang Y
AD  - State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation 
      and Research, China Pharmaceutical University, Nanjing, 211198, China. 
      valianty@hotmail.com.
FAU - Jiao, Shun-Chang
AU  - Jiao SC
AD  - Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 
      100853, China. jiaosc@vip.sina.com.
FAU - Liu, Zhe-Feng
AU  - Liu ZF
AD  - Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 
      100853, China. Lzf1220@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Cytokines)
RN  - 0 (Fcgr1 protein, mouse)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, IgG)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Down-Regulation
MH  - Escherichia coli/*physiology
MH  - Escherichia coli Infections/*immunology
MH  - Humans
MH  - Lipopolysaccharides/immunology
MH  - MAP Kinase Signaling System
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, IgG/genetics/*metabolism
MH  - Sepsis/*immunology
MH  - Toll-Like Receptor 4/*metabolism
OTO - NOTNLM
OT  - ERK
OT  - FcRgamma
OT  - LPS
OT  - TLR4
EDAT- 2018/12/16 06:00
MHDA- 2020/01/01 06:00
CRDT- 2018/12/16 06:00
PHST- 2018/12/16 06:00 [pubmed]
PHST- 2020/01/01 06:00 [medline]
PHST- 2018/12/16 06:00 [entrez]
AID - 10.1007/s12026-018-9039-y [pii]
AID - 10.1007/s12026-018-9039-y [doi]
PST - ppublish
SO  - Immunol Res. 2019 Feb;67(1):77-83. doi: 10.1007/s12026-018-9039-y.