PMID- 30554440
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20201123
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 41
IP  - 5
DP  - 2019 May
TI  - Efficacy of calcium excretion and calcium/creatinine clearance ratio in the 
      differential diagnosis of familial hypocalciuric hypercalcemia and primary 
      hyperparathyroidism.
PG  - 1372-1378
LID - 10.1002/hed.25568 [doi]
AB  - BACKGROUND: Twenty-four-hour renal calcium-excretion (CE) and 
      calcium/creatinine-clearance-ratio (CCCR), respectively, are widely used to rule 
      out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary 
      hyperparathyroidism before surgery. The aim was to evaluate the practicability of 
      CE compared to CCCR. PATIENTS AND METHODS: We analyzed biochemical parameters, 
      surgical treatment, gene mutation results, and long-term follow-up data of 198 
      patients (including 14 patients with FHH) and the discriminative power of CE and 
      CCCR. RESULTS: Twenty four patients (12.1%) had a low CE and 35 patients (20.2%) 
      had a CCCR indicating FHH. However, eight patients with FHH (57.1%) had a normal 
      or increased CE. Correspondingly, only eight cases of FHH (57.1%) were correctly 
      predicted by CCCR. Sensitivity/specificity were 42.9%/89.9% for CE and 
      64.3%/79.9% for CCCR, showing no statistical differences (P = 0.482) between both 
      methods. CONCLUSION: Neither CE nor CCCR was able to distinguish between PHPT and 
      FHH but may help to narrow down potential FHH patients.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Bhangu, Jagdeep Singh
AU  - Bhangu JS
AUID- ORCID: 0000-0002-2917-0420
AD  - Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, 
      Medical University of Vienna, Vienna, Austria.
FAU - Selberherr, Andreas
AU  - Selberherr A
AD  - Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, 
      Medical University of Vienna, Vienna, Austria.
FAU - Brammen, Lindsay
AU  - Brammen L
AD  - Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, 
      Medical University of Vienna, Vienna, Austria.
FAU - Scheuba, Christian
AU  - Scheuba C
AD  - Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, 
      Medical University of Vienna, Vienna, Austria.
FAU - Riss, Philipp
AU  - Riss P
AUID- ORCID: 0000-0003-1472-6606
AD  - Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, 
      Medical University of Vienna, Vienna, Austria.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20181215
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Parathyroid Hormone)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
RN  - Hypocalciuric hypercalcemia, familial, type 1
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/*urine
MH  - Cohort Studies
MH  - Creatinine/*urine
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypercalcemia/blood/*congenital/diagnosis/surgery
MH  - Hyperparathyroidism, Primary/blood/*diagnosis/surgery
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/blood
MH  - Parathyroidectomy/*methods
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Treatment Outcome
OTO - NOTNLM
OT  - calcium excretion
OT  - calcium/creatinine clearance ratio
OT  - familial hypocalciuric hypercalcemia
OT  - parathyroid surgery
OT  - primary hyperparathyroidism
EDAT- 2018/12/17 06:00
MHDA- 2020/11/24 06:00
CRDT- 2018/12/17 06:00
PHST- 2018/04/25 00:00 [received]
PHST- 2018/08/08 00:00 [revised]
PHST- 2018/11/21 00:00 [accepted]
PHST- 2018/12/17 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
PHST- 2018/12/17 06:00 [entrez]
AID - 10.1002/hed.25568 [doi]
PST - ppublish
SO  - Head Neck. 2019 May;41(5):1372-1378. doi: 10.1002/hed.25568. Epub 2018 Dec 15.