PMID- 30556
OWN - NLM
STAT- MEDLINE
DCOM- 19790115
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 6 Suppl
DP  - 1977
TI  - Neuroendocrine control of prolactin in experimental animals.
PG  - 9S-18S
AB  - Hypothalamic regulation of prolactin secretion in animals (mammals) and man 
      appears to be similar, and no significant differences have yet been demonstrated. 
      The hypothalamus contains neurotransmitters and polypeptides that can either 
      inhibit or stimulate prolactin release, although the predominant influence under 
      basal conditions is to inhibit prolactin release. Thus pituitary stalk section or 
      placement of lesions in the basal tuberal region of the hypothalamus results in 
      increased prolactin release and sometimes in initiation of lactation. Among 
      agents in the hypothalamus that can inhibit prolactin release, the most important 
      appear to be an as yet unidentified polypeptide prolactin release inhibiting 
      factor (PIF) and dopamine. There is some evidence that dopamine may account for 
      most, if not all, of the prolactin release inhibiting activity of the 
      hypothalamus. Agents that increase dopamine activity, i.e. L-dopa, monoamine 
      oxidase inhibitors, etc., depress prolactin release. Acetylcholine also can 
      inhibit prolactin release, but it appears to act via the catecholamines. Of the 
      agents in the hypothalamus that stimulate prolactin release, the most important 
      appear to be an as yet uncharacterized polypeptide prolactin releasing factor 
      (PRF), thyrotropin releasing hormone (TRH) and serotonin. TRH is as effective in 
      releasing prolactin as in releasing TSH, but under most physiological states, TSH 
      and prolactin release do not occur together. Serotonin and its precursors, 
      tryptophan and 5-hydroxytryptophan, are powerful releasors of prolactin and have 
      been shown to be involved in some physiological states in which prolactin is 
      released, i.e. during suckling, stress, etc. Other agents in the hypothalamus 
      that can stimulate prolactin release include GABA and some prostaglandins, but 
      these have not yet been shown to be involved in physiological control of 
      prolactin secretion. Exteroceptive stimuli that alter prolactin release act 
      through the CNS and hypothalamus, but some hormones and drugs also can act 
      directly on the pituitary to promote or depress prolactin release.
FAU - Meites, J
AU  - Meites J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Catecholamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 51110-01-1 (Somatostatin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - 9034-47-3 (Prolactin Release-Inhibiting Factors)
RN  - N9YNS0M02X (Acetylcholine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acetylcholine/physiology
MH  - Animals
MH  - Catecholamines/physiology
MH  - Dopamine/physiology
MH  - Feedback
MH  - Female
MH  - Hypothalamus/*physiology
MH  - Male
MH  - Norepinephrine
MH  - Pituitary Gland, Anterior/*physiology
MH  - Prolactin/*metabolism
MH  - Prolactin Release-Inhibiting Factors/physiology
MH  - Rats
MH  - Serotonin/physiology
MH  - Somatostatin/physiology
MH  - Stress, Physiological/physiopathology
MH  - Thyrotropin-Releasing Hormone/physiology
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 1977/01/01 00:00
MHDA- 1977/01/01 00:01
CRDT- 1977/01/01 00:00
PHST- 1977/01/01 00:00 [pubmed]
PHST- 1977/01/01 00:01 [medline]
PHST- 1977/01/01 00:00 [entrez]
AID - 10.1111/j.1365-2265.1977.tb03334.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1977;6 Suppl:9S-18S. doi: 
      10.1111/j.1365-2265.1977.tb03334.x.