PMID- 30557342
OWN - NLM
STAT- MEDLINE
DCOM- 20190606
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 12
DP  - 2018
TI  - Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary 
      artery disease in Egyptian postmenopausal females.
PG  - e0208038
LID - 10.1371/journal.pone.0208038 [doi]
LID - e0208038
AB  - C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family 
      comprises of 15 proteins that posses important implications in energy 
      homeostasis, infection and inflammation. However, their roles in diabetes 
      mellitus (DM) and its vascular complications have not been completely assessed. 
      This works aims to study the association of two CTRPs; 3 and 9, with 
      pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and 
      biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery 
      disease (CAD). METHODS: Biochemical markers and serum levels of CTRPs and MCP-1 
      were measured in 86 postmenopausal females. Subjects were divided over four 
      groups; 13 apparent healthy subjects as control (group I), 29 patients with CAD 
      (group II), 29 patients with T2D >/=5 years (group III) and 15 patients with CAD 
      secondary to T2D (group IV). Serum CTRP3, CTRP9, MCP-1 and insulin were measured 
      by ELISA. RESULTS: Serum CTRP3 levels were found to be significantly higher in 
      group III and IV, whereas, it was significantly lower in group II on comparing to 
      group I. While, CTRP9 levels were significantly decreased in group II, III and IV 
      on comparing to group I. MCP-1 levels were found to be significantly increased in 
      groups II, III and IV on comparison with group I. Both CTRPs were significantly 
      negatively correlated with each other. While MCP-1 was significantly correlated 
      negatively to CTRP9. CONCLUSION: This study associates the possible role of 
      CTRP3, CTRP9 and MCP-1/CCL2 in the diagnosis/prognosis of CAD complication in T2D 
      postmenopausal females.
FAU - Ahmed, Sara F
AU  - Ahmed SF
AD  - Biochemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical 
      Industries, Future University in Egypt, 5th settlement, Cairo, Egypt.
FAU - Shabayek, Marwa I
AU  - Shabayek MI
AD  - Biochemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical 
      Industries, Future University in Egypt, 5th settlement, Cairo, Egypt.
FAU - Abdel Ghany, Mostafa E
AU  - Abdel Ghany ME
AD  - Cardiology Department, Faculty of Medicine, Al-Azhar University, Nasr city, 
      Cairo, Egypt.
FAU - El-Hefnawy, Mohamed H
AU  - El-Hefnawy MH
AD  - National Institute of Diabetes and Endocrinology (NIDE), Kasr El Ainy, Cairo, 
      Egypt.
FAU - El-Mesallamy, Hala O
AU  - El-Mesallamy HO
AUID- ORCID: 0000-0001-8190-536X
AD  - Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union 
      Authority St. Abassia, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20181217
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (C1QTNF3 protein, human)
RN  - 0 (C1QTNF9B protein, human)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycoproteins)
RN  - 0 (Tumor Necrosis Factor Receptor-Associated Peptides and Proteins)
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Adiponectin/*blood
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Coronary Artery Disease/blood/*diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Egypt
MH  - Female
MH  - Glycoproteins/*blood
MH  - Humans
MH  - Middle Aged
MH  - Postmenopause
MH  - Prognosis
MH  - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
MH  - Tumor Necrosis Factors/*blood
PMC - PMC6296499
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/12/18 06:00
MHDA- 2019/06/07 06:00
PMCR- 2018/12/17
CRDT- 2018/12/18 06:00
PHST- 2018/07/18 00:00 [received]
PHST- 2018/11/09 00:00 [accepted]
PHST- 2018/12/18 06:00 [entrez]
PHST- 2018/12/18 06:00 [pubmed]
PHST- 2019/06/07 06:00 [medline]
PHST- 2018/12/17 00:00 [pmc-release]
AID - PONE-D-18-21342 [pii]
AID - 10.1371/journal.pone.0208038 [doi]
PST - epublish
SO  - PLoS One. 2018 Dec 17;13(12):e0208038. doi: 10.1371/journal.pone.0208038. 
      eCollection 2018.