PMID- 30558202
OWN - NLM
STAT- MEDLINE
DCOM- 20190301
LR  - 20200225
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 15
IP  - 12
DP  - 2018 Dec 14
TI  - Prenatal Exposure to Environmental Tobacco Smoke and Early Development of 
      Children in Rural Guizhou Province, China.
LID - 10.3390/ijerph15122866 [doi]
LID - 2866
AB  - BACKGROUND: There is a substantial body of evidence supporting the association 
      between maternal active smoking during pregnancy and child development, but the 
      association between prenatal exposure to environmental tobacco smoke (ETS) and 
      early child development has not been well documented. This cross-sectional study 
      examines the association between prenatal exposure to ETS and the development of 
      children in their first two years of life. METHODS: We interviewed the primary 
      caregivers of 446 children under two years old in rural Guizhou Province, China. 
      Based on self-reported assessments about whether the mother was exposed to ETS 
      during pregnancy, we divided the children into the ETS-exposed group or the 
      non-exposed group. Sociodemographic information was collected through a 
      questionnaire. The cognitive, language, motor, and socioemotional abilities of 
      children were assessed using the Bayley Scales of Infant Development III 
      (BSID-III). A multivariate linear regression model adjusting for confounding 
      variables was used to estimate the association of interest. RESULTS: About 60% of 
      mothers experienced ETS exposure during pregnancy. Cognitive and language scores 
      were lower among children in the ETS-exposed group. When adjusting for 
      characteristics of the child, the mother, the household, and village fixed 
      effects, prenatal exposure to ETS was associated with lower cognition scores 
      (-3.41; 95% confidence interval (CI): -6.39 to -0.42; p = 0.03) and language 
      scores (-3.01; 95% CI: -5.39 to -0.09; p = 0.04). Frequency of prenatal exposure 
      to ETS was also negatively associated with language development (-0.48; 95% CI: 
      -0.87 to -0.09; p = 0.02) before children reached two years old. CONCLUSIONS: 
      Prenatal exposure to ETS is negatively associated with the cognitive and language 
      development of rural young children within their first two years of life. The 
      government should take action to raise public awareness about the negative 
      effects of tobacco use, with an emphasis on the protection of pregnant women and 
      their children, in order to carry through comprehensive smoke-free laws in rural 
      areas, while also increasing tobacco taxation.
FAU - He, Yang
AU  - He Y
AD  - School of Advanced Agricultural Sciences, Peking University, Beijing 100871, 
      China. heyangivy@pku.edu.cn.
FAU - Luo, Renfu
AU  - Luo R
AD  - School of Advanced Agricultural Sciences, Peking University, Beijing 100871, 
      China. luorf.ccap@pku.edu.cn.
AD  - The college of Economics and Business administration, Jiangxi Agricultural 
      University, Nanchang 330029, China. luorf.ccap@pku.edu.cn.
FAU - Wang, Tianyi
AU  - Wang T
AD  - School of Advanced Agricultural Sciences, Peking University, Beijing 100871, 
      China. tianyi_34@163.com.
FAU - Gao, Jingjing
AU  - Gao J
AD  - School of Advanced Agricultural Sciences, Peking University, Beijing 100871, 
      China. gaojj@pku.edu.cn.
FAU - Liu, Chengfang
AU  - Liu C
AD  - School of Advanced Agricultural Sciences, Peking University, Beijing 100871, 
      China. cfliu.ccap@pku.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181214
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Child Development
MH  - Child, Preschool
MH  - China
MH  - Cross-Sectional Studies
MH  - Developmental Disabilities/diagnosis/*etiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Linear Models
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*etiology
MH  - Risk Factors
MH  - *Rural Health
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC6313710
OTO - NOTNLM
OT  - early development
OT  - environmental tobacco smoke
OT  - prenatal exposure to ETS
COIS- The authors declare no conflict of interest.
EDAT- 2018/12/19 06:00
MHDA- 2019/03/02 06:00
PMCR- 2018/12/01
CRDT- 2018/12/19 06:00
PHST- 2018/10/31 00:00 [received]
PHST- 2018/12/08 00:00 [revised]
PHST- 2018/12/10 00:00 [accepted]
PHST- 2018/12/19 06:00 [entrez]
PHST- 2018/12/19 06:00 [pubmed]
PHST- 2019/03/02 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - ijerph15122866 [pii]
AID - ijerph-15-02866 [pii]
AID - 10.3390/ijerph15122866 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2018 Dec 14;15(12):2866. doi: 
      10.3390/ijerph15122866.