PMID- 30558629
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20200225
IS  - 1749-8090 (Electronic)
IS  - 1749-8090 (Linking)
VI  - 13
IP  - 1
DP  - 2018 Dec 17
TI  - Video assisted thoracic surgery vs. thoracotomy for locally advanced lung 
      squamous cell carcinoma after neoadjuvant chemotherapy.
PG  - 128
LID - 10.1186/s13019-018-0813-7 [doi]
LID - 128
AB  - BACKGROUND: Surgery is an important part of multidisciplinary treatment strategy 
      for locally advanced lung squamous cell carcinoma (LSCC), but insufficient 
      evidence supports the feasibility and safety of video assisted thoracic surgery 
      (VATS) following neoadjuvant chemotherapy for locally advanced LSCC. This study 
      aims to compare perioperative data and long-term survival of locally advanced 
      LSCC patients between VATS and thoracotomy after neoadjuvant chemotherapy. 
      METHODS: We retrospectively collected the clinical and pathological information 
      of patients with locally advanced LSCC who underwent surgical resection after 
      neoadjuvant chemotherapy from October 2013 to October 2017. All patients were 
      divided into two groups (thoracotomy and VATS) and were compared the differences 
      in perioperative, oncological and survival outcomes. RESULTS: A total of 81 
      patients were analyzed in this study (67 thoracotomy and 14 VATS). VATS provided 
      less postoperative pain (P = 0.005) and produced less volume of chest drainage 
      (P = 0.019) than thoracotomy, but the number of resected lymph nodes was less in 
      VATS group (P = 0.011). However, there was no significant difference in the 
      number of resected lymph node stations and the rate of nodal upstaging between 
      two groups. The mean disease free survival (DFS) was 32.7 +/- 2.7 months for the 
      thoracotomy group and 31.8 +/- 3.0 months for the VATS group (P = 0.335); the 
      corresponding overall survival (OS) was 41.7 +/- 2.2 months and 36.4 +/- 4.1 months 
      (P = 0.925). CONCLUSION: In selected patients with locally advanced LSCC, VATS 
      played a positive role in postoperative recovery and associated similar survival 
      outcome compared with thoracotomy after neoadjuvant chemotherapy.
FAU - Fang, Likui
AU  - Fang L
AD  - Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310003, China.
FAU - Wang, Luming
AU  - Wang L
AD  - Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310003, China.
FAU - Wang, Yiqing
AU  - Wang Y
AD  - Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310003, China.
FAU - Lv, Wang
AU  - Lv W
AD  - Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310003, China.
FAU - Hu, Jian
AU  - Hu J
AD  - Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310003, China. dr_hujian@zju.edu.cn.
LA  - eng
GR  - 2014C03032/Major science and technology projects of Zhejiang province/
GR  - 2015ZZ007/Key research project of traditional Chinese medicine science and 
      technology plan in Zhejiang Province/
GR  - 2017YFC0113500/National Key R&D Program of China/
PT  - Comparative Study
PT  - Journal Article
DEP - 20181217
PL  - England
TA  - J Cardiothorac Surg
JT  - Journal of cardiothoracic surgery
JID - 101265113
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/mortality/*surgery
MH  - Carcinoma, Squamous Cell/mortality/*surgery
MH  - Chest Tubes/statistics & numerical data
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Neoplasms/mortality/pathology/*surgery
MH  - Lymph Node Excision/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Neoadjuvant Therapy/methods
MH  - Pain, Postoperative/epidemiology/etiology
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Thoracic Surgery, Video-Assisted/adverse effects/*methods
MH  - Thoracotomy/adverse effects/*methods
MH  - Treatment Outcome
PMC - PMC6297983
OTO - NOTNLM
OT  - Locally advanced lung squamous cell carcinoma
OT  - Neoadjuvant chemotherapy
OT  - Thoracotomy
OT  - Video assisted thoracic surgery
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study protocol was approved by 
      the Institutional Review Board of the First Affiliated Hospital of Zhejiang 
      University, School of Medicine. CONSENT FOR PUBLICATION: Not applicable. 
      COMPETING INTERESTS: The authors declare that they have no competing interests. 
      PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional 
      claims in published maps and institutional affiliations.
EDAT- 2018/12/19 06:00
MHDA- 2019/01/29 06:00
PMCR- 2018/12/17
CRDT- 2018/12/19 06:00
PHST- 2018/09/12 00:00 [received]
PHST- 2018/12/03 00:00 [accepted]
PHST- 2018/12/19 06:00 [entrez]
PHST- 2018/12/19 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/12/17 00:00 [pmc-release]
AID - 10.1186/s13019-018-0813-7 [pii]
AID - 813 [pii]
AID - 10.1186/s13019-018-0813-7 [doi]
PST - epublish
SO  - J Cardiothorac Surg. 2018 Dec 17;13(1):128. doi: 10.1186/s13019-018-0813-7.