PMID- 30559150
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20200309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 39
IP  - 8
DP  - 2019 Feb 20
TI  - Active Zone Proteins RIM1alphabeta Are Required for Normal Corticostriatal Transmission 
      and Action Control.
PG  - 1457-1470
LID - 10.1523/JNEUROSCI.1940-18.2018 [doi]
AB  - Dynamic regulation of synaptic transmission at cortical inputs to the dorsal 
      striatum is considered critical for flexible and efficient action learning and 
      control. Presynaptic mechanisms governing the properties and plasticity of 
      glutamate release from these inputs are not fully understood, and the 
      corticostriatal synaptic processes that support normal action learning and 
      control remain unclear. Here we show in male and female mice that conditional 
      deletion of presynaptic proteins RIM1alphabeta (RIM1) from excitatory cortical neurons 
      impairs corticostriatal synaptic transmission in the dorsolateral striatum. Key 
      forms of presynaptic G-protein-coupled receptor-mediated short- and long-term 
      striatal plasticity are spared following RIM1 deletion. Conditional RIM1 KO mice 
      show heightened novelty-induced locomotion and impaired motor learning on the 
      accelerating rotarod. They further show heightened self-paced instrumental 
      responding for food and impaired learning of a habitual instrumental response 
      strategy. Together, these findings reveal a selective role for presynaptic RIM1 
      in neurotransmitter release at prominent basal ganglia synapses, and provide 
      evidence that RIM1-dependent processes help to promote the refinement of skilled 
      actions, constrain goal-directed behaviors, and support the learning and use of 
      habits.SIGNIFICANCE STATEMENT Our daily functioning hinges on the ability to 
      flexibly and efficiently learn and control our actions. How the brain encodes 
      these capacities is unclear. Here we identified a selective role for presynaptic 
      proteins RIM1alphabeta in controlling glutamate release from cortical inputs to the 
      dorsolateral striatum, a brain structure critical for action learning and 
      control. Behavioral analysis of mice with restricted genetic deletion of RIM1alphabeta 
      further revealed roles for RIM1alphabeta-dependent processes in the learning and 
      refinement of motor skills and the balanced expression of goal-directed and 
      habitual actions.
CI  - Copyright (c) 2019 the authors 0270-6474/19/391457-14$15.00/0.
FAU - Kupferschmidt, David A
AU  - Kupferschmidt DA
AD  - Section on Synaptic Pharmacology & In Vivo Neural Function, Laboratory for 
      Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health, Rockville, Maryland 20852, and.
AD  - Integrative Neuroscience Section, National Institute of Neurological Disorders 
      and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Augustin, Shana M
AU  - Augustin SM
AD  - Section on Synaptic Pharmacology & In Vivo Neural Function, Laboratory for 
      Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health, Rockville, Maryland 20852, and.
FAU - Johnson, Kari A
AU  - Johnson KA
AD  - Section on Synaptic Pharmacology & In Vivo Neural Function, Laboratory for 
      Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health, Rockville, Maryland 20852, and.
FAU - Lovinger, David M
AU  - Lovinger DM
AD  - Section on Synaptic Pharmacology & In Vivo Neural Function, Laboratory for 
      Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health, Rockville, Maryland 20852, and 
      lovindav@mail.nih.gov.
LA  - eng
GR  - R00 AA025403/AA/NIAAA NIH HHS/United States
GR  - ZIA AA000416/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181217
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Rims1 protein, mouse)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
CIN - J Neurosci. 2019 Oct 2;39(40):7812-7814. PMID: 31578279
MH  - Animals
MH  - Basal Ganglia/physiology
MH  - Cerebral Cortex/*physiology
MH  - Conditioning, Operant/physiology
MH  - Corpus Striatum/*physiology
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - GTP-Binding Proteins/deficiency/genetics/*physiology
MH  - Glutamic Acid/physiology
MH  - Habits
MH  - Learning/physiology
MH  - Learning Disabilities/genetics/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Skills/physiology
MH  - Nerve Tissue Proteins/deficiency/genetics/*physiology
MH  - Neuronal Plasticity
MH  - Patch-Clamp Techniques
MH  - Pyramidal Cells/physiology
MH  - Receptors, G-Protein-Coupled/physiology
MH  - Rotarod Performance Test
MH  - Synaptic Transmission/physiology
PMC - PMC6381247
OTO - NOTNLM
OT  - RIM1
OT  - action
OT  - corticostriatal
OT  - learning
OT  - plasticity
OT  - transmission
EDAT- 2018/12/19 06:00
MHDA- 2019/12/31 06:00
PMCR- 2019/08/20
CRDT- 2018/12/19 06:00
PHST- 2018/07/26 00:00 [received]
PHST- 2018/11/13 00:00 [revised]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2018/12/19 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2018/12/19 06:00 [entrez]
PHST- 2019/08/20 00:00 [pmc-release]
AID - JNEUROSCI.1940-18.2018 [pii]
AID - 1940-18 [pii]
AID - 10.1523/JNEUROSCI.1940-18.2018 [doi]
PST - ppublish
SO  - J Neurosci. 2019 Feb 20;39(8):1457-1470. doi: 10.1523/JNEUROSCI.1940-18.2018. 
      Epub 2018 Dec 17.