PMID- 30560019
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2186-3644 (Print)
IS  - 2186-361X (Electronic)
IS  - 2186-3644 (Linking)
VI  - 7
IP  - 4
DP  - 2018 Nov
TI  - Filaggrin, major basic protein and leukotriene B4: Biomarkers for adult patients 
      of bronchial asthma, atopic dermatitis and allergic rhinitis.
PG  - 264-270
LID - 10.5582/irdr.2018.01111 [doi]
AB  - Bronchial asthma (BA), atopic dermatitis (AD), and allergic rhinitis (AR) are 
      well known atopic disorders with complex etiologies. This study was undertaken to 
      investigate the role of filaggrin, eosinophil major basic protein (MBP) and 
      leukotriene B4 (LTB4) in patients with BA, AD, and AR. Sera from 1,246 patients 
      with different atopic disorders and 410 normal healthy controls were collected 
      and were evaluated for filaggrin, MBP and LTB4 by specific sandwich ELISAs, 
      whereas immunoglobulin E (IgE) was used as a positive control for atopic 
      patients. Serum analysis showed that filaggrin levels were remarkably high in 
      patients with AD and in patients with multiple (mixed) atopic disorders (p < 
      0.001), whereas its levels in BA and AR patients were low but much higher than in 
      normal human sera (p < 0.01). MBP levels were also high in AR, BA and mixed 
      atopic patients, whereas AD patients showed no increase of MBP (p > 0.05). In 
      contrast, LTB4 level was found to be significantly low in all tested atopic 
      patients groups as compared to the levels of LTB4 present in normal human sera (p 
      < 0.001). In conclusion, these findings support an association between filaggrin, 
      MBP or LTB4 and atopic disorders. Our data strongly suggest that filaggrin, MBP 
      or LTB4 might be useful in elucidating the mechanisms involved in the 
      pathogenesis of these atopic disorders.
FAU - A, Ghada
AU  - A G
AD  - Department of Dermatology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Rasheed, Zafar
AU  - Rasheed Z
AD  - Department of Medical Biochemistry, College of Medicine, Qassim University, 
      Buraidah, Saudi Arabia.
FAU - Salama, Ragaa H
AU  - Salama RH
AD  - Department of Medical Biochemistry, College of Medicine, Qassim University, 
      Buraidah, Saudi Arabia.
FAU - Salem, Tarek
AU  - Salem T
AD  - Department of Medical Biochemistry, College of Medicine, Qassim University, 
      Buraidah, Saudi Arabia.
FAU - Ahmed, Ahmed A
AU  - Ahmed AA
AD  - Research Center, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
FAU - Zedan, Khaled
AU  - Zedan K
AD  - Department of Pediatric, College of Medicine, Qassim University, Buraidah, Saudi 
      Arabia.
FAU - El-Moniem, Alaa Abd
AU  - El-Moniem AA
AD  - Department of Medicine, College of Medicine, Qassim University, Buraidah, Saudi 
      Arabia.
FAU - Elkholy, Maha
AU  - Elkholy M
AD  - Department of Medicine, College of Medicine, Qassim University, Buraidah, Saudi 
      Arabia.
FAU - A, Ahmad
AU  - A A
AD  - Department of Dermatology, College of Medicine, Qassim University, Buraidah, 
      Saudi Arabia.
FAU - Alzolibani, Abdullateef A
AU  - Alzolibani AA
AD  - Department of Dermatology, College of Medicine, Qassim University, Buraidah, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Intractable Rare Dis Res
JT  - Intractable & rare diseases research
JID - 101586847
PMC - PMC6290844
OTO - NOTNLM
OT  - Bronchial asthma
OT  - LTB4
OT  - MBP
OT  - allergic rhinitis
OT  - atopic dermatitis
OT  - filaggrin
EDAT- 2018/12/19 06:00
MHDA- 2018/12/19 06:01
PMCR- 2018/11/01
CRDT- 2018/12/19 06:00
PHST- 2018/12/19 06:00 [entrez]
PHST- 2018/12/19 06:00 [pubmed]
PHST- 2018/12/19 06:01 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 10.5582/irdr.2018.01111 [doi]
PST - ppublish
SO  - Intractable Rare Dis Res. 2018 Nov;7(4):264-270. doi: 10.5582/irdr.2018.01111.