PMID- 30561087
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20190718
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 97
IP  - 5
DP  - 2019 Aug
TI  - Central retinal thickness following panretinal photocoagulation using a multispot 
      semi-automated pattern-scanning laser to treat ischaemic diabetic retinopathy: 
      Treatment in one session compared with four monthly sessions.
PG  - e680-e687
LID - 10.1111/aos.14002 [doi]
AB  - PURPOSE: To compare central retinal thickness (CRT) after panretinal 
      photocoagulation (PRP) with a multispot semi-automated PAttern-SCAnning Laser 
      (PASCAL) in one session (SS-PRP) versus four monthly sessions (MS-PRP) in 
      diabetic retinopathy. METHODS: Multicentre, prospective, randomized, 
      single-blinded, controlled trial evaluating the noninferiority of SS-PRP versus 
      MS-PRP for CRT measured with macular spectral-domain optical coherence tomography 
      (SD-OCT), with a 9-month follow-up in patients presenting severe nonproliferative 
      diabetic retinopathy (DR) or mild proliferative DR without macular oedema (ME) at 
      baseline. RESULTS: Ninety-seven eyes of 97 participants with a mean age of 
      57.0 +/- 14.2 years were included. The mean change of CRT from baseline to 9 months 
      was not statistically different in SS-PRP or in MS-PRP: +16.9 +/- 28.3 mum versus 
      +24.7 +/- 31.8 mum, respectively (p = 0.224). The variation in mean best-corrected 
      visual acuity (BCVA) from baseline to 9 months was similar in both groups: 
      -1.1 +/- 6.5 letters versus -0.6 +/- 6.2 letters (p = 0.684). The number of patients 
      with stabilization of DR was not statistically different between the two groups. 
      No severe complication was recorded in either group. CONCLUSION: This study 
      showed the noninferiority of PRP performed in one session versus four monthly 
      sessions with a PASCAL concerning central retinal thickness for treating mild 
      proliferative or severe nonproliferative DR without ME at baseline.
CI  - (c) 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Gabrielle, Pierre-Henry
AU  - Gabrielle PH
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, Centre des Sciences du Gout et de 
      l'Alimentation, UMR1324 INRA, 6265 CNRS, University of Bourgogne Franche-Comte, 
      Dijon, France.
FAU - Massin, Pascale
AU  - Massin P
AD  - Department of Ophthalmology, Hopital Lariboisiere, AP-HP, Universite Paris 7 - 
      Sorbonne Paris Cite, Paris, France.
FAU - Kodjikian, Laurent
AU  - Kodjikian L
AD  - Department of Ophthalmology, Croix-Rousse teaching Hospital, Hospices Civil de 
      Lyon, Lyon, France.
FAU - Erginay, Ali
AU  - Erginay A
AD  - Department of Ophthalmology, Hopital Lariboisiere, AP-HP, Universite Paris 7 - 
      Sorbonne Paris Cite, Paris, France.
FAU - Pallot, Charlotte
AU  - Pallot C
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, Centre des Sciences du Gout et de 
      l'Alimentation, UMR1324 INRA, 6265 CNRS, University of Bourgogne Franche-Comte, 
      Dijon, France.
FAU - Jonval, Lysiane
AU  - Jonval L
AD  - Department of Clinical Research and Epidemiology, University Hospital, Dijon, 
      France.
FAU - Soudry, Agnes
AU  - Soudry A
AD  - Department of Clinical Research and Epidemiology, University Hospital, Dijon, 
      France.
FAU - Couturier, Aude
AU  - Couturier A
AD  - Department of Ophthalmology, Hopital Lariboisiere, AP-HP, Universite Paris 7 - 
      Sorbonne Paris Cite, Paris, France.
FAU - Vardanian-Vartin, Cristina
AU  - Vardanian-Vartin C
AD  - Department of Ophthalmology, Croix-Rousse teaching Hospital, Hospices Civil de 
      Lyon, Lyon, France.
FAU - Bron, Alain M
AU  - Bron AM
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, Centre des Sciences du Gout et de 
      l'Alimentation, UMR1324 INRA, 6265 CNRS, University of Bourgogne Franche-Comte, 
      Dijon, France.
FAU - Creuzot-Garcher, Catherine
AU  - Creuzot-Garcher C
AUID- ORCID: 0000-0002-3587-4598
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, Centre des Sciences du Gout et de 
      l'Alimentation, UMR1324 INRA, 6265 CNRS, University of Bourgogne Franche-Comte, 
      Dijon, France.
LA  - eng
GR  - Dijon University Hospital/
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20181218
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Diabetic Retinopathy/diagnosis/physiopathology/*surgery
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Laser Coagulation/*methods
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Retina/*pathology/surgery
MH  - Single-Blind Method
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
MH  - Treatment Outcome
MH  - Visual Acuity
OTO - NOTNLM
OT  - diabetic retinopathy
OT  - macular oedema
OT  - panretinal photocoagulation
OT  - pattern scanning laser
EDAT- 2018/12/19 06:00
MHDA- 2019/07/19 06:00
CRDT- 2018/12/19 06:00
PHST- 2018/06/30 00:00 [received]
PHST- 2018/11/21 00:00 [accepted]
PHST- 2018/12/19 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
PHST- 2018/12/19 06:00 [entrez]
AID - 10.1111/aos.14002 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2019 Aug;97(5):e680-e687. doi: 10.1111/aos.14002. Epub 2018 Dec 
      18.