PMID- 30562552
OWN - NLM
STAT- MEDLINE
DCOM- 20190215
LR  - 20220331
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 232
DP  - 2019 Mar 25
TI  - The chemistry and biological activities of Peperomia pellucida (Piperaceae): A 
      critical review.
PG  - 90-102
LID - S0378-8741(18)32327-4 [pii]
LID - 10.1016/j.jep.2018.12.021 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Peperomia pellucida (L.) Kunth is an annual weed 
      with a preference to humid places with reduced solar radiation. This plant is 
      mainly distributed in the Neotropics, Africa, Southeast Asia, and Australia. It 
      is popularly employed in the treatment of a variety of health conditions such as 
      abscesses, abdominal pain, skin sores, conjunctivitis, measles, and kidney 
      troubles. Several studies have also described its antimicrobial, cytotoxic, 
      antidiabetic and a variety of other bioactivities. THE AIM OF THE REVIEW: The aim 
      of this work is to evaluate, using a critical review, the present ethnomedicinal 
      applications, phytochemistry and pharmacological studies of P. pellucida 
      essential oils (EOs) and extracts from different locations around the world. 
      MATERIALS AND METHODS: This review was performed through an online survey of the 
      ethnomedicinal practices, chemical compositions and pharmacological applications 
      of P. pellucida EOs and extracts. The data were mainly obtained from online 
      journals and books published in English, Portuguese and Spanish. The information 
      was collected from websites such as Google, Google Scholar, PubMed, Science 
      Direct, ResearchGate and other online databases that provided more information 
      about this herb. RESULTS: Peperomia pellucida bioactivities such as 
      antimicrobial, cytotoxic, antioxidant, fracture healing, antidiabetic and 
      anti-hypercholesterolemia have been described in several literature sources. 
      Nonetheless, most reports only provide the phytochemical screening of extracts, 
      which does not allow the identification of the active compounds. From these 
      studies, some reported constituents are not included in the Dictionary of Natural 
      Products (DNP), which raises questions toward their identification. In addition, 
      some biological assays were even performed without standard controls for 
      comparison which also makes these results questionable. CONCLUSION: This review 
      evaluates data regarding the phytopharmaceutical potential of P. pellucida. In 
      general, several important aspects were questionable or missing in these 
      manuscripts, which points out the need of more investigation on the 
      pharmacological properties and phytochemical compositions of this herb.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Alves, Nayara Sabrina F
AU  - Alves NSF
AD  - Programa de Pos-Graduacao em Biotecnologia, Universidade Federal do Para, 
      66075-900 Belem, Brazil. Electronic address: nayara.alves@icb.ufpa.br.
FAU - Setzer, William N
AU  - Setzer WN
AD  - Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 
      35899, USA; Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 
      84043, USA. Electronic address: setzerw@uah.edu.
FAU - da Silva, Joyce Kelly R
AU  - da Silva JKR
AD  - Programa de Pos-Graduacao em Biotecnologia, Universidade Federal do Para, 
      66075-900 Belem, Brazil. Electronic address: joycekellys@ufpa.br.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181215
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Phytochemicals)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Medicine, Traditional
MH  - *Peperomia/chemistry
MH  - Phytochemicals/analysis/*pharmacology
MH  - *Phytotherapy
OTO - NOTNLM
OT  - Ethnomedicinal practices
OT  - Peperomia pellucida
OT  - Pharmacological applications
OT  - Phytochemistry
EDAT- 2018/12/19 06:00
MHDA- 2019/02/16 06:00
CRDT- 2018/12/19 06:00
PHST- 2018/07/04 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2018/12/14 00:00 [accepted]
PHST- 2018/12/19 06:00 [pubmed]
PHST- 2019/02/16 06:00 [medline]
PHST- 2018/12/19 06:00 [entrez]
AID - S0378-8741(18)32327-4 [pii]
AID - 10.1016/j.jep.2018.12.021 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2019 Mar 25;232:90-102. doi: 10.1016/j.jep.2018.12.021. Epub 
      2018 Dec 15.