PMID- 30562872
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 75
IP  - 2
DP  - 2017 Feb
TI  - [Metformin-dependent metabolic reprogramming contributes to efficient anti-tumor 
      immunity].
PG  - 323-328
AB  - The rate of cancer incidence and mortality of Type 2 diabetes patients who were 
      taking metformin seem to be decreased, comparing with those taking other drugs. 
      We recently pro- vided compelling evidence showing that the effect might be 
      mediated by immune system, thus, the reversion of exhausted tumor infiltrating 
      CD8T lymphocytes (CD8TIL). Glycolysis is essential in CD8T cell function. 
      However, the metabolism of CD8TIL is locked in a state of oxidative 
      phosphorylation (OxPhos) dominant over glycolysis because of interaction between 
      immune checkpoints and their ligands, and because of extremely low concentration 
      of glu- cose in tumor microenvironment. Metformin increases the glycolysis 
      efficiency, resulting in the conversion of CD8TIL to more active effector memory 
      to fight against cancers.
FAU - Tomonobu, Nahoko
AU  - Tomonobu N
FAU - Eikawa, Shingo
AU  - Eikawa S
FAU - Udono, Heiichiro
AU  - Udono H
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Humans
MH  - Immunologic Memory/drug effects
MH  - Metformin/*pharmacology
MH  - Neoplasms/immunology/*metabolism/*therapy
EDAT- 2017/02/01 00:00
MHDA- 2017/02/01 00:01
CRDT- 2018/12/19 06:00
PHST- 2018/12/19 06:00 [entrez]
PHST- 2017/02/01 00:00 [pubmed]
PHST- 2017/02/01 00:01 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2017 Feb;75(2):323-328.