PMID- 30562960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231005
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 4
IP  - 4
DP  - 2018 Dec 17
TI  - Understanding Pathogenesis and Care Challenges of Immune Reconstitution 
      Inflammatory Syndrome in Fungal Infections.
LID - 10.3390/jof4040139 [doi]
LID - 139
AB  - Immune deficiency of diverse etiology, including human immunodeficiency virus 
      (HIV), antineoplastic agents, immunosuppressive agents used in solid organ 
      recipients, immunomodulatory therapy, and other biologics, all promote invasive 
      fungal infections. Subsequent voluntary or unintended immune recovery may induce 
      an exaggerated inflammatory response defining immune reconstitution inflammatory 
      syndrome (IRIS), which causes significant mortality and morbidity. 
      Fungal-associated IRIS raises several diagnostic and management issues. Mostly 
      studied with Cryptococcus, it has also been described with other major fungi 
      implicated in human invasive fungal infections, such as Pneumocystis, 
      Aspergillus, Candida, and Histoplasma. Furthermore, the understanding of IRIS 
      pathogenesis remains in its infancy. This review summarizes current knowledge 
      regarding the clinical characteristics of IRIS depending on fungal species and 
      existing strategies to predict, prevent, and treat IRIS in this patient 
      population, and tries to propose a common immunological background to fungal 
      IRIS.
FAU - Delliere, Sarah
AU  - Delliere S
AUID- ORCID: 0000-0003-3821-1762
AD  - Medical School, Paris-Descartes University, APHP, Necker-Enfants Malades 
      Hospital, Infectious Disease Center Necker-Pasteur, IHU Imagine, 75015 Paris, 
      France. sarah.delliere@gmail.com.
FAU - Guery, Romain
AU  - Guery R
AD  - Medical School, Paris-Descartes University, APHP, Necker-Enfants Malades 
      Hospital, Infectious Disease Center Necker-Pasteur, IHU Imagine, 75015 Paris, 
      France. romain.guery@aphp.fr.
FAU - Candon, Sophie
AU  - Candon S
AD  - Medical School, Paris-Descartes University, INSERM U1151-CNRS UMR 8253APHP, 
      Necker-Enfants Malades Hospital, APHP, Clinical Immunology, 75015 Paris, France. 
      sophie.candon@inserm.fr.
FAU - Rammaert, Blandine
AU  - Rammaert B
AD  - Medical School, Poitiers University, Poitiers, France; Poitiers University 
      Hospital, Infectious Disease Unit, Poitiers, France; INSERM U1070, 86022 
      Poitiers, France. blandine.rammaert.paltrie@univ-poitiers.fr.
FAU - Aguilar, Claire
AU  - Aguilar C
AD  - Medical School, Paris-Descartes University, APHP, Necker-Enfants Malades 
      Hospital, Infectious Disease Center Necker-Pasteur, IHU Imagine, 75015 Paris, 
      France. ag_claire@yahoo.fr.
FAU - Lanternier, Fanny
AU  - Lanternier F
AD  - Medical School, Paris-Descartes University, APHP, Necker-Enfants Malades 
      Hospital, Infectious Disease Center Necker-Pasteur, IHU Imagine, 75015 Paris, 
      France. fanny.lanternier@aphp.fr.
AD  - Pasteur Institute, Molecular Mycology Unit, National Reference Center for 
      Invasive Fungal Disease and Antifungals, CNRS UMR 2000, 75015 Paris, France. 
      fanny.lanternier@aphp.fr.
FAU - Chatenoud, Lucienne
AU  - Chatenoud L
AD  - Medical School, Paris-Descartes University, INSERM U1151-CNRS UMR 8253APHP, 
      Necker-Enfants Malades Hospital, APHP, Clinical Immunology, 75015 Paris, France. 
      lucienne.chatenoud@inserm.fr.
FAU - Lortholary, Olivier
AU  - Lortholary O
AD  - Medical School, Paris-Descartes University, APHP, Necker-Enfants Malades 
      Hospital, Infectious Disease Center Necker-Pasteur, IHU Imagine, 75015 Paris, 
      France. olivier.lortholary@aphp.fr.
AD  - Pasteur Institute, Molecular Mycology Unit, National Reference Center for 
      Invasive Fungal Disease and Antifungals, CNRS UMR 2000, 75015 Paris, France. 
      olivier.lortholary@aphp.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181217
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC6308948
OTO - NOTNLM
OT  - fungal immunity
OT  - immune reconstitution inflammatory syndrome
OT  - invasive fungal infections
OT  - mycoses
COIS- The authors declare no conflict of interest.
EDAT- 2018/12/20 06:00
MHDA- 2018/12/20 06:01
PMCR- 2018/12/17
CRDT- 2018/12/20 06:00
PHST- 2018/11/19 00:00 [received]
PHST- 2018/12/14 00:00 [revised]
PHST- 2018/12/15 00:00 [accepted]
PHST- 2018/12/20 06:00 [entrez]
PHST- 2018/12/20 06:00 [pubmed]
PHST- 2018/12/20 06:01 [medline]
PHST- 2018/12/17 00:00 [pmc-release]
AID - jof4040139 [pii]
AID - jof-04-00139 [pii]
AID - 10.3390/jof4040139 [doi]
PST - epublish
SO  - J Fungi (Basel). 2018 Dec 17;4(4):139. doi: 10.3390/jof4040139.