PMID- 30565440
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 42
IP  - 6
DP  - 2018 Dec
TI  - Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and 
      Management.
PG  - 451-464
LID - 10.4093/dmj.2018.0190 [doi]
AB  - Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease 
      characterized by a less intensive autoimmune process and a broad clinical 
      phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features 
      with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by 
      LADA are initially insulin independent and recognizable only by testing for 
      islet-cell autoantibodies, it could be difficult to identify LADA in clinical 
      setting and a high misdiagnosis rate still remains among patients with T2DM. 
      Ideally, islet-cell autoantibodies screening should be performed in subjects with 
      newly diagnosed T2DM, ensuring a closer monitoring of those resulted positive and 
      avoiding treatment of hyperglycaemia which might increase the rate of beta-cells 
      loss. Thus, since the autoimmune process in LADA seems to be slower than in 
      classical T1DM, there is a wider window for new therapeutic interventions that 
      may slow down beta-cell failure. This review summarizes the current understanding of 
      LADA, by evaluating data from most recent studies, the actual gaps in diagnosis 
      and management. Finally, we critically highlight and discuss novel findings and 
      future perspectives on the therapeutic approach in LADA.
CI  - Copyright (c) 2018 Korean Diabetes Association.
FAU - Pieralice, Silvia
AU  - Pieralice S
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, 
      Italy.
FAU - Pozzilli, Paolo
AU  - Pozzilli P
AUID- ORCID: 0000-0001-5090-636X
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, 
      Italy.
AD  - Centre of Immunobiology, Blizard Institute, Barts and the London School of 
      Medicine, Queen Mary University of London, London, UK. p.pozzilli@unicampus.it.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC6300440
OTO - NOTNLM
OT  - Diabetes mellitus, type 1
OT  - Hypoglycemic agents
OT  - Insulin
OT  - Insulin resistance
OT  - Insulin-secreting cells
OT  - Latent autoimmune diabetes in adults
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/12/20 06:00
MHDA- 2018/12/20 06:01
PMCR- 2018/12/01
CRDT- 2018/12/20 06:00
PHST- 2018/09/20 00:00 [received]
PHST- 2018/11/14 00:00 [accepted]
PHST- 2018/12/20 06:00 [entrez]
PHST- 2018/12/20 06:00 [pubmed]
PHST- 2018/12/20 06:01 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 42.451 [pii]
AID - 10.4093/dmj.2018.0190 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2018 Dec;42(6):451-464. doi: 10.4093/dmj.2018.0190.