PMID- 30566412
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1473-6551 (Electronic)
IS  - 1350-7540 (Linking)
VI  - 32
IP  - 1
DP  - 2019 Feb
TI  - Potential retinal biomarkers for dementia: what is new?
PG  - 82-91
LID - 10.1097/WCO.0000000000000645 [doi]
AB  - PURPOSE OF REVIEW: To summarize the current findings on clinical retinal diseases 
      and retinal imaging changes with dementia, focusing on Alzheimer's disease. 
      RECENT FINDINGS: Studies observed that clinical retinal diseases such as 
      age-related macular degeneration, open-angle glaucoma and diabetic retinopathy 
      are related to dementia, but the associations are not entirely consistent. In 
      terms of the retinal neuronal structure, multiple retinal neuronal layers are 
      significantly thinner in Alzheimer's disease dementia, such as the parapapillary 
      retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer 
      (GC-IPL). Recent studies further demonstrated that macular GC-IPL and macular 
      RNFL are also significantly thinner in the preclinical stage of Alzheimer's 
      disease. A thinner RNFL is also associated with a significantly increased risk of 
      developing both cognitive decline and Alzheimer's disease dementia. In addition, 
      studies consistently showed that retinal vascular changes are associated with 
      poorer cognitive performance, as well as prevalent and incident Alzheimer's 
      disease dementia. SUMMARY: The current findings support the concept that changes 
      in the retina, particular in retinal neuronal structure and vasculature, can 
      reflect the status of cerebral neuronal structure and vasculature, highlighting 
      the potential role of retinal changes as biomarkers of dementia.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong.
FAU - Chan, Victor T T
AU  - Chan VTT
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong.
FAU - Mok, Vincent C
AU  - Mok VC
AD  - Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, 
      Division of Neurology, Department of Medicine and Therapeutics, The Chinese 
      University of Hong Kong, Hong Kong.
FAU - Chen, Christopher
AU  - Chen C
AD  - Memory Aging and Cognition Centre, National University Health System, Singapore.
AD  - Department of Pharmacology, National University of Singapore.
FAU - Wong, Tien Y
AU  - Wong TY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre.
AD  - Duke-NUS Medical School, National University of Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Neurol
JT  - Current opinion in neurology
JID - 9319162
RN  - 0 (Biomarkers)
MH  - Biomarkers
MH  - Dementia/*diagnosis/diagnostic imaging/pathology
MH  - Humans
MH  - Retina/*diagnostic imaging/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Neurons/*pathology
MH  - Tomography, Optical Coherence
EDAT- 2018/12/20 06:00
MHDA- 2019/08/14 06:00
CRDT- 2018/12/20 06:00
PHST- 2018/12/20 06:00 [entrez]
PHST- 2018/12/20 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
AID - 00019052-201902000-00015 [pii]
AID - 10.1097/WCO.0000000000000645 [doi]
PST - ppublish
SO  - Curr Opin Neurol. 2019 Feb;32(1):82-91. doi: 10.1097/WCO.0000000000000645.