PMID- 30567572
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 20
IP  - 1
DP  - 2018 Dec 20
TI  - Dynamic changes in injured myocardium, very early after acute myocardial 
      infarction, quantified using T1 mapping cardiovascular magnetic resonance.
PG  - 82
LID - 10.1186/s12968-018-0506-3 [doi]
LID - 82
AB  - BACKGROUND: It has recently been suggested that myocardial oedema follows a 
      bimodal pattern early post ST-segment elevation myocardial infarction (STEMI). 
      Yet, water content, quantified using tissue desiccation, did not return to normal 
      values unlike oedema quantified by cardiovascular magnetic resonance (CMR) 
      imaging. We studied the temporal changes in the extent and intensity of injured 
      myocardium using T1-mapping technique within the first week after STEMI. METHODS: 
      A first group (n = 31) underwent 3 acute 3 T CMR scans (time-point (TP) < 3 h, 
      24 h and 6 days), including cine, native shortened modified look-locker inversion 
      recovery T1 mapping, T2* mapping and late gadolinium enhancement (LGE). A second 
      group (n = 17) had a single scan at 24 h with an additional T2-weighted sequence 
      to assess the difference in the extent of area-at-risk (AAR) compared to 
      T1-mapping. RESULTS: The mean T1 relaxation time value within the AAR of the 
      first group was reduced after 24 h (P < 0.001 for TP1 vs.TP2) and subsequently 
      increased at 6 days (P = 0.041 for TP2 vs.TP3). However, the extent of AAR 
      quantified using T1-mapping did not follow the same course, and no change was 
      detected between TP1&TP2 (P = 1.0) but was between TP2 &TP3 (P = 0.019). In the 
      second group, the extent of AAR was significantly larger on T1-mapping compared 
      to T2-weighted (42 +/- 15% vs. 39 +/- 15%, P = 0.025). No change in LGE was detected 
      while microvascular obstruction and intra-myocardial haemorrhage peaked at 
      different time points within the first week of reperfusion. CONCLUSION: The 
      intensity of oedema post-STEMI followed a bimodal pattern; while the extent of 
      AAR did not track the same course. This discrepancy has implications for use of 
      CMR in this context and may explain the previously reported disagreement between 
      oedema quantified by imaging and tissue desiccation.
FAU - Alkhalil, Mohammad
AU  - Alkhalil M
AUID- ORCID: 0000-0002-3088-8878
AD  - Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of 
      Oxford, Oxford, UK.
AD  - Division of Cardiovascular Medicine, BHF Centre of Research Excellence, 
      University of Oxford, Oxford, UK.
FAU - Borlotti, Alessandra
AU  - Borlotti A
AD  - Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of 
      Oxford, Oxford, UK.
FAU - De Maria, Giovanni Luigi
AU  - De Maria GL
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK.
FAU - Gaughran, Lisa
AU  - Gaughran L
AD  - Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of 
      Oxford, Oxford, UK.
FAU - Langrish, Jeremy
AU  - Langrish J
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK.
FAU - Lucking, Andrew
AU  - Lucking A
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK.
FAU - Ferreira, Vanessa
AU  - Ferreira V
AD  - Division of Cardiovascular Medicine, University of Oxford Centre for Clinical 
      Magnetic Resonance Research (OCMR), Oxford, UK.
FAU - Kharbanda, Rajesh K
AU  - Kharbanda RK
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK.
FAU - Banning, Adrian P
AU  - Banning AP
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK.
FAU - Channon, Keith M
AU  - Channon KM
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK.
AD  - Division of Cardiovascular Medicine, BHF Centre of Research Excellence, 
      University of Oxford, Oxford, UK.
FAU - Dall'Armellina, Erica
AU  - Dall'Armellina E
AD  - Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of 
      Oxford, Oxford, UK.
FAU - Choudhury, Robin P
AU  - Choudhury RP
AD  - Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of 
      Oxford, Oxford, UK. robin.choudhury@cardiov.ox.ac.uk.
AD  - Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University 
      Hospitals, Oxford, OX3 9DU, UK. robin.choudhury@cardiov.ox.ac.uk.
AD  - Division of Cardiovascular Medicine, BHF Centre of Research Excellence, 
      University of Oxford, Oxford, UK. robin.choudhury@cardiov.ox.ac.uk.
LA  - eng
GR  - FS/13/71/30378/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181220
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Aged
MH  - Contrast Media/administration & dosage
MH  - Edema, Cardiac/*diagnostic imaging/pathology/physiopathology
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Meglumine/administration & dosage
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Organometallic Compounds/administration & dosage
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/*diagnostic imaging/pathology/physiopathology
MH  - Time Factors
PMC - PMC6300907
OTO - NOTNLM
OT  - Area at risk
OT  - STEMI
OT  - T1-mapping
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study protocol was approved by 
      the local ethics committee and conducted in accordance with the Declaration of 
      Helsinki. All participants provided written informed consent. CONSENT FOR 
      PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they 
      have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2018/12/21 06:00
MHDA- 2019/03/15 06:00
PMCR- 2018/12/20
CRDT- 2018/12/21 06:00
PHST- 2018/06/11 00:00 [received]
PHST- 2018/11/11 00:00 [accepted]
PHST- 2018/12/21 06:00 [entrez]
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/12/20 00:00 [pmc-release]
AID - S1097-6647(23)00619-1 [pii]
AID - 506 [pii]
AID - 10.1186/s12968-018-0506-3 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2018 Dec 20;20(1):82. doi: 10.1186/s12968-018-0506-3.