PMID- 30568448
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 14
DP  - 2018
TI  - Association of HLA alleles with autism.
PG  - 3259-3265
LID - 10.2147/NDT.S186673 [doi]
AB  - BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous 
      neurodevelopmental disorders known by impaired social interaction and activities 
      and abnormal repetitive behavior. As a multifactorial disorder, several genetic 
      and immunological factors have been shown to be implicated in its pathogenesis. 
      METHODS: Among them are certain human leukocyte antigen (HLA) alleles. In the 
      current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients 
      and 180 age, gender, and ethnic-matched healthy controls. RESULTS: After 
      Boferroni correction no allele or haplotype was associated with genetic 
      susceptibility to ASD in Iranian population. CONCLUSION: Future studies are 
      needed to assess contribution of immunological factors such as HLA alleles in ASD 
      pathogenesis.
FAU - Sayad, Arezou
AU  - Sayad A
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran, s.ghafourifard@sbmu.ac.ir.
FAU - Akbari, Mohammad Taghi
AU  - Akbari MT
AD  - Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Noroozi, Rezvan
AU  - Noroozi R
AD  - Photochemistry Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Omrani, Mir Davood
AU  - Omrani MD
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran, s.ghafourifard@sbmu.ac.ir.
AD  - Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Inoko, Hidetoshi
AU  - Inoko H
AD  - Department of Molecular Life Science, Tokai University, Hiratsuka, Japan.
FAU - Taheri, Mohammad
AU  - Taheri M
AD  - Student Research Committee, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran, mohammad_823@yahoo.com.
FAU - Ghafouri-Fard, Soudeh
AU  - Ghafouri-Fard S
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran, s.ghafourifard@sbmu.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20181127
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC6267725
OTO - NOTNLM
OT  - HLA typing
OT  - autism
OT  - immune response
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/12/21 06:00
MHDA- 2018/12/21 06:01
PMCR- 2018/11/27
CRDT- 2018/12/21 06:00
PHST- 2018/12/21 06:00 [entrez]
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2018/12/21 06:01 [medline]
PHST- 2018/11/27 00:00 [pmc-release]
AID - ndt-14-3259 [pii]
AID - 10.2147/NDT.S186673 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2018 Nov 27;14:3259-3265. doi: 10.2147/NDT.S186673. 
      eCollection 2018.