PMID- 30569647
OWN - NLM
STAT- MEDLINE
DCOM- 20190522
LR  - 20190522
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 50
IP  - 11
DP  - 2018 Dec
TI  - Exploring the role of antigen presenting cells in male genital tract.
PG  - e13120
LID - 10.1111/and.13120 [doi]
AB  - Antigen presenting cells (APCs) are a critical mediator between innate and 
      adaptive immune response. APCs have diverse functions in physiological and 
      pathological conditions, such as maintenance of tissue homoeostasis, prevention 
      of autoimmunity and defence against pathogenic microorganisms and cancer cells. 
      Dendritic cells (DCs) and macrophages (Mvarphis) are "professional" APCs that 
      internalise and process allo- and autoantigens; then, resulting peptides are 
      exhibited together with major histocompatibility complex (MHC) molecules 
      expressed at the cell surface. MHC-antigen complexes are presented to "naive" T 
      cells, thereby stimulating proliferation and differentiation of effector and 
      regulatory T cells. The aim of this review was to summarise current understanding 
      of DCs and Mvarphis in testis and epididymis. Male reproductive tract environment is 
      characterised by contradictory needs for tolerance against autoantigenic germ 
      cells that appear after the establishment of central tolerance, and the capacity 
      to mount pro-inflammatory innate immune responses against a wide array of 
      sexually transmitted pathogens. Therefore, exploration of the role of APCs in 
      male reproductive organs is helpful to understand mechanisms of male infertility 
      associated with disruption of the delicate equilibrium between immune privilege 
      and inflammation.
CI  - (c) 2018 Blackwell Verlag GmbH.
FAU - Guazzone, Vanesa A
AU  - Guazzone VA
AUID- ORCID: 0000-0001-9070-2388
AD  - Universidad de Buenos Aires, Facultad de Medicina, Departamento de Biologia 
      Celular e Histologia/Unidad Academica II., Buenos Aires, Argentina.
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad de Buenos 
      Aires, Instituto de Investigaciones Biomedicas (INBIOMED), Buenos Aires, 
      Argentina.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Autoantigens)
SB  - IM
MH  - Autoantigens/immunology
MH  - Dendritic Cells/*immunology
MH  - Epididymis/cytology/*immunology
MH  - Germ Cells/immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Innate
MH  - Infertility, Male/*immunology
MH  - Macrophages/*immunology
MH  - Major Histocompatibility Complex/immunology
MH  - Male
MH  - Testis/cytology/*immunology
OTO - NOTNLM
OT  - dendritic cells
OT  - epididymis
OT  - macrophages
OT  - testis
EDAT- 2018/12/21 06:00
MHDA- 2019/05/23 06:00
CRDT- 2018/12/21 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/06/25 00:00 [revised]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/12/21 06:00 [entrez]
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2019/05/23 06:00 [medline]
AID - 10.1111/and.13120 [doi]
PST - ppublish
SO  - Andrologia. 2018 Dec;50(11):e13120. doi: 10.1111/and.13120.