PMID- 30570309
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20201214
IS  - 1939-2117 (Electronic)
IS  - 0022-006X (Linking)
VI  - 87
IP  - 2
DP  - 2019 Feb
TI  - Cognitive behavioral therapy for social activation in recent-onset psychosis: 
      Randomized controlled trial.
PG  - 151-160
LID - 10.1037/ccp0000362 [doi]
AB  - OBJECTIVE: Negative symptoms largely account for poor outcome in psychotic 
      disorders but remain difficult to treat. A cognitive-behavioral approach to these 
      symptoms showed promise in chronic schizophrenia patients. We explored whether a 
      combination of group and individual treatment focused on social activation 
      (CBTsa) could benefit patients recently diagnosed with a psychotic disorder. 
      METHOD: A single-blind randomized controlled trial enrolled 99 participants 
      recently diagnosed with schizophrenia or a related disorder that received 
      treatment as usual (TAU; n = 50), or TAU plus CBTsa (n = 49). Negative symptoms 
      (Brief Negative Symptom Scale) and social withdrawal (Positive and Negative 
      Syndrome Scale) were primary outcomes. Secondary outcome measures included 
      dysfunctional beliefs (Dysfunctional Attitudes Scale-Defeatist Performance 
      Attitude), stigma Internalized Stigma of Mental Illness Scale (ISMIS), and 
      symptom severity and functioning as measured with the Global Assessment of 
      Functioning (GAF). Outcomes were compared directly posttreatment and at follow-up 
      (6 months posttreatment). RESULTS: Intention-to-treat analyses showed significant 
      improvement in GAF symptoms (p = .02, d = 0.36) and a decrease in negative 
      symptoms on trend level (p = .08, d = -0.29) in CBTsa compared to TAU at 
      posttreatment. These group differences were no longer apparent at 6 months 
      follow-up. Social withdrawal and negative symptoms improved over time in both 
      conditions. CONCLUSIONS: The current trial showed small positive effects on 
      symptom severity posttreatment but did not demonstrate maintenance of longer-term 
      effects in favor of the CBTsa group. Findings suggest that the treatment duration 
      may have been too short to change dysfunctional beliefs, a potentially important 
      maintaining factor of negative symptom severity. Longer intervention periods in 
      later, more stable stages of the illness when intensive standard treatment has 
      tapered off may yield more beneficial effects. (PsycINFO Database Record (c) 2019 
      APA, all rights reserved).
FAU - Pos, Karin
AU  - Pos K
AD  - Department of Psychiatry.
FAU - Franke, Nathalie
AU  - Franke N
AD  - Department of Psychiatry.
FAU - Smit, Filip
AU  - Smit F
AD  - Netherlands Institute of Mental Health and Addiction (Trimbos Institute).
FAU - Wijnen, Ben F M
AU  - Wijnen BFM
AD  - Netherlands Institute of Mental Health and Addiction (Trimbos Institute).
FAU - Staring, Anton B P
AU  - Staring ABP
AD  - Altrecht Psychiatric Institute.
FAU - Van der Gaag, Mark
AU  - Van der Gaag M
AUID- ORCID: 0000-0002-3525-6415
AD  - Department of Clinical Psychology.
FAU - Meijer, Carin
AU  - Meijer C
AD  - Department of Psychiatry.
FAU - de Haan, Lieuwe
AU  - de Haan L
AD  - Department of Psychiatry.
FAU - Velthorst, Eva
AU  - Velthorst E
AUID- ORCID: 0000-0002-9240-2909
AD  - Department of Psychiatry.
FAU - Schirmbeck, Frederike
AU  - Schirmbeck F
AUID- ORCID: 0000-0003-1700-0958
AD  - Department of Psychiatry.
LA  - eng
GR  - Netherlands Organisation for Health Research and Development/
GR  - Netherlands Organisation for Scientific Research/
GR  - Seaver Foundation/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181220
PL  - United States
TA  - J Consult Clin Psychol
JT  - Journal of consulting and clinical psychology
JID - 0136553
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Attitude
MH  - *Cognitive Behavioral Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/psychology/*therapy
MH  - Schizophrenia/*therapy
MH  - Schizophrenic Psychology
MH  - Single-Blind Method
MH  - Social Behavior
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2018/12/21 06:00
MHDA- 2019/03/16 06:00
CRDT- 2018/12/21 06:00
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2018/12/21 06:00 [entrez]
AID - 2018-63732-001 [pii]
AID - 10.1037/ccp0000362 [doi]
PST - ppublish
SO  - J Consult Clin Psychol. 2019 Feb;87(2):151-160. doi: 10.1037/ccp0000362. Epub 
      2018 Dec 20.