PMID- 30570867
OWN - NLM
STAT- MEDLINE
DCOM- 20190925
LR  - 20190925
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 23
IP  - 5
DP  - 2018 Sep-Oct
TI  - MiR-24 promotes migration and invasion of non-small cell lung cancer by targeting 
      ZNF367.
PG  - 1413-1419
AB  - PURPOSE: Non-small lung cancer (NSCLC) is one of most common cancers worldwide. 
      microRNAs (miRNAs) play an important role in animal biological processes, such as 
      cell growth, differentiation and apoptosis. The aim of this study was to 
      investigate whether MiR-24 can regulate cell proliferation of NSCLC by targeting 
      ZNF367. METHODS: Real time quantitative PCR (qRT-PCR) was used to detect the 
      expression levels of MiR-24 and ZNF367. Western blot assay was employed to 
      analyze the protein levels. Luciferase reporter assay was used to test the target 
      gene of MiR-24. MTT assay was used to detect cell proliferation. RESULTS: MiR-24 
      was significantly up-regulated in NSCLC tissues compared with their corresponding 
      nontumorous tissues (p<0.05). Over-expression of MiR-24 could significantly 
      promoted cell migration and invasion (p<0.05). ZNF367 was a downstream target of 
      MiR-24 and down-regulated by MiR-24. Knockdown of ZNF367 remarkably promoted 
      NSCLC cell proliferation (p<0.05). CONCLUSIONS: The novel identified 
      MiR-24/ZNF367 axis offers new insights into tumorigenesis of NSCLC and a new 
      biomarker for NSCLC treatment.
FAU - Liu, Zhenli
AU  - Liu Z
AD  - Department of Respiratory Medicine, Affiliated Hospital of Jining Medical 
      University, Jining, China.
FAU - Jiang, Luning
AU  - Jiang L
FAU - Zhang, Guangning
AU  - Zhang G
FAU - Li, Shuang
AU  - Li S
FAU - Jiang, Xuefeng
AU  - Jiang X
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (MIRN24 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (ZNF367 protein, human)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/genetics/*metabolism/pathology
MH  - Cell Movement/physiology
MH  - Cell Proliferation
MH  - Cell Separation
MH  - Humans
MH  - Kruppel-Like Transcription Factors/genetics/*metabolism
MH  - Lung Neoplasms/genetics/*metabolism/pathology
MH  - MicroRNAs/genetics/*metabolism
MH  - Transfection
EDAT- 2018/12/21 06:00
MHDA- 2019/09/26 06:00
CRDT- 2018/12/21 06:00
PHST- 2018/12/21 06:00 [entrez]
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PST - ppublish
SO  - J BUON. 2018 Sep-Oct;23(5):1413-1419.