PMID- 30572003
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20211204
IS  - 1872-8006 (Electronic)
IS  - 0304-4165 (Linking)
VI  - 1863
IP  - 3
DP  - 2019 Mar
TI  - M(en)TORship lessons on life and death by the integrated stress response.
PG  - 644-649
LID - S0304-4165(18)30372-6 [pii]
LID - 10.1016/j.bbagen.2018.12.009 [doi]
AB  - Cells employ pro-survival and pro-adaptive pathways to cope with different forms 
      of environmental stress. When stress is excessive, and the damage caused by it is 
      unsustainable, cells engage pro-death pathways, which are in place to protect the 
      host from the deleterious effects of harmed cells. Two important pathways that 
      determine the balance between survival and death of stressed cells are the 
      integrated stress response (ISR) and the mammalian target of rapamycin (mTOR), 
      both of which converge at the level of mRNA translation. The two pathways have 
      established avenues of communication to control their activity and determine the 
      fate of stressed cells in a context-dependent manner. The functional interplay 
      between the ISR and mTOR may have significant ramifications in the development 
      and treatment of human diseases such as diabetes, neurodegeneration and cancer.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Koromilas, Antonis E
AU  - Koromilas AE
AD  - Lady Davis Institute for Medical Research-McGill University, Sir Mortimer B. 
      Davis-Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada; Department of 
      Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H4A 3T2, 
      Canada. Electronic address: antonis.koromilas@mcgill.ca.
LA  - eng
GR  - MOP-38160/CIHR/Canada
GR  - MOP-13713/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20181217
PL  - Netherlands
TA  - Biochim Biophys Acta Gen Subj
JT  - Biochimica et biophysica acta. General subjects
JID - 101731726
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - *Cell Death/genetics
MH  - *Cell Proliferation/genetics
MH  - Cell Survival/genetics
MH  - Endoplasmic Reticulum/metabolism
MH  - Humans
MH  - Protein Biosynthesis/genetics
MH  - Stress, Physiological/genetics/*physiology
MH  - TOR Serine-Threonine Kinases/*physiology
OTO - NOTNLM
OT  - Cell death
OT  - Cell proliferation
OT  - Endoplasmic reticulum stress
OT  - Mammalian target of rapamycin
OT  - Nutrient deprivation
OT  - Oxidative stress
OT  - Protein phosphorylation
OT  - Translation initiation factor eIF2
OT  - mRNA translation
EDAT- 2018/12/21 06:00
MHDA- 2019/11/05 06:00
CRDT- 2018/12/21 06:00
PHST- 2018/10/31 00:00 [received]
PHST- 2018/12/11 00:00 [revised]
PHST- 2018/12/14 00:00 [accepted]
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/12/21 06:00 [entrez]
AID - S0304-4165(18)30372-6 [pii]
AID - 10.1016/j.bbagen.2018.12.009 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):644-649. doi: 
      10.1016/j.bbagen.2018.12.009. Epub 2018 Dec 17.