PMID- 30572228
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20200106
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 71
IP  - 1
DP  - 2019 Feb
TI  - Ascorbic acid attenuates cognitive impairment and brain oxidative stress in 
      ovariectomized mice.
PG  - 133-138
LID - S1734-1140(18)30204-4 [pii]
LID - 10.1016/j.pharep.2018.10.001 [doi]
AB  - BACKGROUND: Menopause is associated with increased oxidative stress and memory 
      impairment. Based on the antioxidant property of ascorbic acid (AA), It's effect 
      on cognitive function, the serum level of the brain-derived neurotrophic factor 
      (BDNF) and the activity of antioxidant enzymes within the brain in ovariectomized 
      (OVX) mice was investigated. METHODS: AA (100, 300 and 500 mg/kg), was orally 
      administrated per day in OVX mice for 30 days. Tactile learning and working 
      memory were evaluated by the novel object recognition task and T-maze continuous 
      alternation task, respectively. The levels of serum BDNF were measured and 
      animals' brains were analyzed for the superoxide dismutase (SOD) and glutathione 
      peroxidase (GPx) activity. RESULTS: AA prevented from the deleterious effects of 
      ovariectomy on learning memory (300 and 500 mg/kg) and working memory (100 and 
      500 mg/kg). The serum BDNF level was also increased in OVX animals treated with 
      AA (100 and 500 mg/kg). Furthermore, AA (500 mg/kg) increased the SOD and GPx 
      activity in the brain of OVX animals. CONCLUSIONS: Collectively, the results of 
      the present study suggest that AA might be an appropriate choice in loss or 
      reduction of estradiol for the amelioration of cognitive impairment.
CI  - Copyright (c) 2018 Institute of Pharmacology, Polish Academy of Sciences. Published 
      by Elsevier B.V. All rights reserved.
FAU - Delrobaei, Fatemeh
AU  - Delrobaei F
AD  - Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, 
      Iran.
FAU - Fatemi, Iman
AU  - Fatemi I
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department 
      of Physiology and Pharmacology, School of Medicine, Rafsanjan University of 
      Medical Sciences, Rafsanjan, Iran.
FAU - Shamsizadeh, Ali
AU  - Shamsizadeh A
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department 
      of Physiology and Pharmacology, School of Medicine, Rafsanjan University of 
      Medical Sciences, Rafsanjan, Iran.
FAU - Allahtavakoli, Mohammad
AU  - Allahtavakoli M
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department 
      of Physiology and Pharmacology, School of Medicine, Rafsanjan University of 
      Medical Sciences, Rafsanjan, Iran. Electronic address: m_alahtavakoli@rums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20181003
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Antioxidants)
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Ascorbic Acid/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Brain/*drug effects/metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cognition/*drug effects
MH  - Cognition Disorders/metabolism/physiopathology/*prevention & control/psychology
MH  - Disease Models, Animal
MH  - Female
MH  - Glutathione Peroxidase/metabolism
MH  - Maze Learning/drug effects
MH  - Memory, Short-Term/drug effects
MH  - *Menopause
MH  - Mice
MH  - *Ovariectomy
MH  - Oxidative Stress/*drug effects
MH  - Recognition, Psychology/drug effects
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Ascorbic acid
OT  - Learning and memory
OT  - Ovariectomy
OT  - Oxidative stress
EDAT- 2018/12/21 06:00
MHDA- 2019/04/04 06:00
CRDT- 2018/12/21 06:00
PHST- 2018/04/16 00:00 [received]
PHST- 2018/09/15 00:00 [revised]
PHST- 2018/10/02 00:00 [accepted]
PHST- 2018/12/21 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2018/12/21 06:00 [entrez]
AID - S1734-1140(18)30204-4 [pii]
AID - 10.1016/j.pharep.2018.10.001 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2019 Feb;71(1):133-138. doi: 10.1016/j.pharep.2018.10.001. Epub 
      2018 Oct 3.