PMID- 30574282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2008-4633 (Print)
IS  - 2008-8469 (Electronic)
IS  - 2008-4633 (Linking)
VI  - 9
IP  - 4
DP  - 2017 Fall
TI  - Effects of Methamphetamine on Testes Histopathology and Spermatogenesis Indices 
      of Adult Male Rats.
PG  - 199-205
AB  - BACKGROUND: Methamphetamine (MAMP) as a recreational drug has devastating effects 
      on the central nervous system (CNS). Several studies have shown that MAMP has 
      inhibitory effects on oogenesis and spermatogenesis, and causes impaired 
      fertility. This study designed to investigate the effect of mAM Padministration 
      on histological changes and spermatogenesis indices in the testis of adult male 
      rats. METHODS: In this experimental study, 50 male Wistar rats were randomly 
      divided into control (received no treatment, n = 10), vehicle (received saline 
      for 7 and 14 days, n = 20), and experimental group [received MAMP, 5 ml/kg, 
      intraperitoneal (IP) for 7 and 14 days, n = 20]. Testicular tissue samples were 
      stained by hematoxylin and eosin (H&E) technique. For histological study, we 
      counted the number of spermatogonia, spermatocytes and Leydig cells. 
      Spermatogenesis indices which include: tubular differentiation index (TDI), 
      spermiogenesis index (SI), repopulation index (RI) and the mean seminiferous 
      tubules diameter (MSTD) were studied. Data were analyzed by one-way ANOVA, using 
      SPSS software. P < 0.05 was considered statistically significant. FINDINGS: This 
      study showed that MAMP caused a significant decrease in number of seminiferous 
      tubules cells and spermatogenesis in treated group compared with the control 
      group. Moreover, results showed a significant decrease in spermatogenesis indices 
      including TDI, SI, RI, and MSTD in 14th day, compared to control group (P < 
      0.001). CONCLUSION: The data showed the adverse effects of MAMP administration 
      (for 7 and 14 days) on testes structure and spermatogenesis indices in rat testis 
      tissue. The underlying mechanism(s) needs further investigation.
FAU - Saberi, Arezoo
AU  - Saberi A
AD  - Neuroscience Research Center, Institute of Neuropharmacology AND Cardiovascular 
      Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman 
      University of Medical Sciences, Kerman, Iran.
FAU - Sepehri, Gholamreza
AU  - Sepehri G
AD  - Professor, Neuroscience Research Center, Institute of Neuropharmacology, Kerman 
      University of Medical Sciences, Kerman, Iran.
FAU - Safi, Zohreh
AU  - Safi Z
AD  - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical 
      Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
FAU - Razavi, Behzad
AU  - Razavi B
AD  - Neuroscience Research Center, Institute of Neuropharmacology AND Cardiovascular 
      Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman 
      University of Medical Sciences, Kerman, Iran.
FAU - Jahandari, Faranak
AU  - Jahandari F
AD  - Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, 
      Kerman University of Medical Sciences, Kerman, Iran.
FAU - Divsalar, Kouros
AU  - Divsalar K
AD  - Neuroscience Research Center, Institute of Neuropharmacology AND Cardiovascular 
      Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman 
      University of Medical Sciences, Kerman, Iran.
FAU - Salarkia, Ehsan
AU  - Salarkia E
AD  - Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Addict Health
JT  - Addiction & health
JID - 101582275
PMC - PMC6294480
OTO - NOTNLM
OT  - Histology
OT  - Methamphetamine
OT  - Rats
OT  - Spermatogenesis
OT  - Testis
EDAT- 2017/10/01 00:00
MHDA- 2017/10/01 00:01
PMCR- 2017/09/01
CRDT- 2018/12/22 06:00
PHST- 2018/12/22 06:00 [entrez]
PHST- 2017/10/01 00:00 [pubmed]
PHST- 2017/10/01 00:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - AHJ-09-199 [pii]
PST - ppublish
SO  - Addict Health. 2017 Fall;9(4):199-205.