PMID- 30574336
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2055-0294 (Print)
IS  - 2055-0294 (Electronic)
IS  - 2055-0294 (Linking)
VI  - 4
DP  - 2018
TI  - Analysis of fall-related adverse events among older adults using the Japanese 
      Adverse Drug Event Report (JADER) database.
PG  - 32
LID - 10.1186/s40780-018-0129-8 [doi]
LID - 32
AB  - BACKGROUND: Falls are a common but serious problem in older adults, and may lead 
      to fractures and bleeding. As many factors, such as medication, aging, and 
      comorbid diseases may simultaneously affect fall-related adverse events (AEs) in 
      older adults, we evaluated the association between fall-related AEs and the use 
      of medication, aging, and comorbid diseases using the Japanese Adverse Drug Event 
      Report (JADER) database. METHODS: We analyzed reports of fall-related AEs 
      associated with alpha-blockers, diuretics, calcium channel blockers, central nervous 
      system (CNS)-active drugs (opioids, benzodiazepines, hypnotics and sedatives, 
      non-selective monoamine reuptake inhibitors, and selective serotonin reuptake 
      inhibitors (SSRI)) in the JADER database using the reporting odds ratio (ROR). 
      For the definition of falls, we used the Preferred Terms of The Medical 
      Dictionary for Regulatory Activities (MedDRA). We used the association rule 
      mining technique to discover undetected associations, such as potential risk 
      factors. RESULTS: The JADER database comprised 430,587 reports between April 2004 
      and November 2016. The RORs (95% CI) of alpha-blockers, diuretics, calcium channel 
      blockers, opioids, benzodiazepines, hypnotics and sedatives, non-selective 
      monoamine reuptake inhibitors, and SSRIs were 1.63 (1.27-2.09), 0.74 (0.63-0.86), 
      1.26 (1.15-1.38), 0.93 (0.80-1.07), 1.83 (1.68-2.01), 1.55 (1.12-2.14), 2.31 
      (1.82-2.95), and 2.86 (2.49-3.29), respectively. From the lift value in the 
      association rule mining, the number of administered CNS-active drugs and patient 
      age were associated with fall-related AEs. Furthermore, the scores of lift for 
      patients with herpes zoster administered calcium channel blockers or 
      benzodiazepines and patients with dementia administered benzodiazepines were 
      high. CONCLUSION: Our results suggest that the number of administered CNS-active 
      drugs and patient age are both associated with fall-related AEs. We recommend 
      that patients with herpes zoster treated with calcium channel blockers and 
      benzodiazepines be closely monitored for fall-related AEs.
FAU - Hatahira, Haruna
AU  - Hatahira H
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
AD  - Department of Pharmacy, Kizawa Memorial Hospital, Kobi-cho, Shimo-kobi 590, 
      Minokamo-shi, Gifu, 505-8503 Japan.
FAU - Hasegawa, Shiori
AU  - Hasegawa S
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Sasaoka, Sayaka
AU  - Sasaoka S
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Kato, Yamato
AU  - Kato Y
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Abe, Junko
AU  - Abe J
AD  - Medical Database Co., Ltd., 3-11-10 Higashi, Shibuya-ku, Tokyo, 150-0011 Japan.
FAU - Motooka, Yumi
AU  - Motooka Y
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Fukuda, Akiho
AU  - Fukuda A
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Naganuma, Misa
AU  - Naganuma M
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Nakao, Satoshi
AU  - Nakao S
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Mukai, Ririka
AU  - Mukai R
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Shimada, Kazuyo
AU  - Shimada K
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
FAU - Hirade, Kouseki
AU  - Hirade K
AD  - Department of Pharmacy, Kizawa Memorial Hospital, Kobi-cho, Shimo-kobi 590, 
      Minokamo-shi, Gifu, 505-8503 Japan.
FAU - Kato, Takeshi
AU  - Kato T
AD  - Department of Pharmacy, Kizawa Memorial Hospital, Kobi-cho, Shimo-kobi 590, 
      Minokamo-shi, Gifu, 505-8503 Japan.
FAU - Nakamura, Mitsuhiro
AU  - Nakamura M
AUID- ORCID: 0000-0002-5062-5522
AD  - 1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku 
      nishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: grid.411697.c
LA  - eng
PT  - Journal Article
DEP - 20181217
PL  - England
TA  - J Pharm Health Care Sci
JT  - Journal of pharmaceutical health care and sciences
JID - 101672177
PMC - PMC6296112
OTO - NOTNLM
OT  - Adverse event reporting system
OT  - Benzodiazepine
OT  - Calcium channel blockers
OT  - Fall
OT  - Hypnotics and sedatives
OT  - JADER
COIS- Not applicable.Not applicable.JA is an employee of Medical Database. The rest of 
      the authors have no conflict of interest.Springer Nature remains neutral with 
      regard to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/12/24 06:00
MHDA- 2018/12/24 06:01
PMCR- 2018/12/17
CRDT- 2018/12/22 06:00
PHST- 2018/07/25 00:00 [received]
PHST- 2018/11/14 00:00 [accepted]
PHST- 2018/12/22 06:00 [entrez]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2018/12/24 06:01 [medline]
PHST- 2018/12/17 00:00 [pmc-release]
AID - 129 [pii]
AID - 10.1186/s40780-018-0129-8 [doi]
PST - epublish
SO  - J Pharm Health Care Sci. 2018 Dec 17;4:32. doi: 10.1186/s40780-018-0129-8. 
      eCollection 2018.